In vitro effects of the long-acting somatostatin analogue SMS 201-995 on electrolyte transport by the rabbit ileum.
In vitro effects of the long-acting somatostatin analogue SMS 201-995 on electrolyte transport by the rabbit ileum.
复制标题
长效生长抑素类似物 SMS 201-995 对兔回肠电解质转运的体外影响。
DOI：
10.1016/0016-5085(88)90672-5
复制
发表时间：
1988
期刊：
影响因子：
29.4
通讯作者：
Chang,EB
中科院分区：
文献类型：
--
作者：
Roberts,WG;Fedorak,RN;Chang,EB
We have investigated the in vitro properties of SMS 201–995, a long-acting somatostatin analogue, on electrolyte transport in rabbit ileum. Similar to native somatostatin, serosal addition of this compound inhibits electrogenic anion secretion and stimulates neutral sodium and chloride absorption. Both compounds have similar maximal effects on ion transport; however, the ED50of SMS 201–995 (2.4 × 10−10M) was 60 times less than that for somatostatin. In addition, unlike somatostatin, no inherent tachyphylaxis was observed in response to SMS 201–995. The antisecretory profile of SMS 201–995 was also compared with that of epinephrine. Unlike treatment with epinephrine, pretreatment of tissues with SMS 201–995 did not directly inhibit electrogenic anion secretion stimulated by vasoactive intestinal polypeptide, calcium ionophore A23187, and bethanechol. In contrast, this agent blocked vasoactive intestinal polypeptide and bethanechol inhibition of net sodium absorption. We conclude that SMS 201–995 has several unique in vitro properties that may explain its greater biologic activity compared with that of somatostatin. Its effects on secretagogue-stimulated electrogenic anion secretion and electroneutral NaCl absorption appear to differ.
登录
查看更多内容
长效生长抑素类似物 (SMS 201-995) 对胰腺霍乱患者的作用。
影响因子：
158.5
作者：
P. Maton;T. O'dorisio;B. Howe;K. Mcarthur;J. Howard;J. Cherner;T. Malarkey;M. Collen;J. Gardner;R. Jensen
通讯作者：
R. Jensen
用长效生长抑素类似物长期治疗转移性胰腺内分泌肿瘤期间症状缓解。
影响因子：
--
作者：
J. Ch'ng;J. Anderson;S. Williams;D. Carr;S. Bloom
通讯作者：
S. Bloom
影响因子：
158.5
作者：
KVOLS, LK;MOERTEL, CG;HAHN, RG
通讯作者：
HAHN, RG
生长抑素对肠蠕动的影响
影响因子：
1.3
作者：
S. Efendić;O. Mattsson
通讯作者：
O. Mattsson
影响因子：
--
作者：
M. Field;D. Fromm;I. Mccoll
通讯作者：
I. Mccoll