Animal models of colitis-associated carcinogenesis.
Animal models of colitis-associated carcinogenesis.
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结肠炎相关的癌变模型。
DOI：
10.1155/2011/342637
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发表时间：
2011
影响因子：
--
通讯作者：
Mizoguchi E
中科院分区：
文献类型：
--
作者：
Kanneganti M;Mino-Kenudson M;Mizoguchi E
炎症性肠病（IBD）是一组影响个体一生的慢性炎症性疾病。 尽管 IBD 的病因和发病机制在很大程度上尚不清楚，但对结肠炎动物模型的研究表明，宿主/微生物相互作用的失调是 IBD 发生的必要条件。 长期患有 IBD 的患者患结肠炎相关癌症 (CAC) 的风险增加，尤其是在初次诊断结肠炎 10 年后，尽管 CAC 病例的绝对数量相对较少。癌症风险似乎与疾病活动性没有直接关系，但与疾病持续时间/程度、原发性硬化性胆管炎并发症和结肠癌家族史有关。 特别是，结肠上皮细胞 (CEC) 和固有层免疫细胞持续高水平地产生炎症介质，包括细胞因子和趋化因子，可能与 CAC 的发病机制密切相关。 在本文中，我们总结了 CAC 的动物模型，并回顾了继发于肠道慢性炎症条件的 CEC 致癌变化发展的细胞和分子机制。 它可能为我们在不久的将来开发一类治疗IBD和CAC的新型治疗药物提供一些线索。
Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that affect individuals throughout life. Although the etiology and pathogenesis of IBD are largely unknown, studies with animal models of colitis indicate that dysregulation of host/microbial interactions are requisite for the development of IBD. Patients with long-standing IBD have an increased risk for developing colitis-associated cancer (CAC), especially 10 years after the initial diagnosis of colitis, although the absolute number of CAC cases is relatively small. The cancer risk seems to be not directly related to disease activity, but is related to disease duration/extent, complication of primary sclerosing cholangitis, and family history of colon cancer. In particular, high levels and continuous production of inflammatory mediators, including cytokines and chemokines, by colonic epithelial cells (CECs) and immune cells in lamina propria may be strongly associated with the pathogenesis of CAC. In this article, we have summarized animal models of CAC and have reviewed the cellular and molecular mechanisms underlining the development of carcinogenic changes in CECs secondary to the chronic inflammatory conditions in the intestine. It may provide us some clues in developing a new class of therapeutic agents for the treatment of IBD and CAC in the near future.
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影响因子：
50.3
作者：
Bollrath, Julia;Phesse, Toby J.;Greten, Florian R.
通讯作者：
Greten, Florian R.
影响因子：
4.4
作者：
Beatty, Pamela L.;Plevy, Scott E.;Finn, Olivera J.
通讯作者：
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影响因子：
16.2
作者：
BURMER, GC;CRISPIN, DA;RABINOVITCH, PS
通讯作者：
RABINOVITCH, PS
影响因子：
29.4
作者：
Bertone, ER;Giovannucci, EL;Johnson, LD
通讯作者：
Johnson, LD
环氧酶-2抑制剂Celecoxib在人乳腺癌细胞中的生长抑制作用的基础机制。
影响因子：
7.4
作者：
Basu, GD;Pathangey, LB;Tinder, TL;Gendler, SJ;Mukherjee, P
通讯作者：
Mukherjee, P