Signals from the dorsal blastopore lip region during gastrulation bias the ectoderm toward a nonepidermal pathway of differentiation in Xenopus laevis.
Signals from the dorsal blastopore lip region during gastrulation bias the ectoderm toward a nonepidermal pathway of differentiation in Xenopus laevis.
复制标题
原肠胚形成期间来自背侧胚孔唇区域的信号使外胚层偏向非洲爪蟾的非表皮分化途径。
DOI:
10.1016/0012-1606(89)90307-2
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发表时间:
1989
影响因子:
2.7
通讯作者:
Phillips,CR
中科院分区:
文献类型:
--
作者:
Savage,R;Phillips,CR
Epi 1, a monoclonal antibody, was generated against an epidermal specific epithelial antigen; it does not stain neural epithelium. We have used Epi 1 as a marker to determine when the spatial patterns delineating neural from nonneural epithelium become established. We used ventral ectoderm in a sandwich assay to show that signals from the central blastopore lip region, passing through the plane of the ectoderm sheet, define the pattern and boundary characteristics of Epi 1 expression. The dorsal blastopore lip at stages 10 and 12 are the strongest in inhibiting Epi 1 expression. The involuted chordamesoderm has only a limited inhibitory effect on Epi 1 expression in ventral ectoderm recombinates and does not appear to establish pattern boundaries. We suggest that the blastopore lip region establishes a preneural bias in the adjacent ectoderm prior to the interaction of the latter with chordamesoderm.
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DOI:
--
发表时间:
1988
期刊:
Laboratory investigation; a journal of technical methods and pathology
影响因子:
--
作者:
D. Kuhns;Wright Dg;J. Nath;S. Kaplan;R. Basford
通讯作者:
R. Basford
DOI:
--
发表时间:
1985-03
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
G. Grynkiewicz;M. Poenie;Roger Y. TsienB
通讯作者:
G. Grynkiewicz;M. Poenie;Roger Y. TsienB
DOI:
--
发表时间:
1983
期刊:
The American journal of pathology
影响因子:
--
作者:
Ward,PA;Duque,RE;Sulavik,MC;Johnson,KJ
通讯作者:
Johnson,KJ
影响因子:
4.8
作者:
Y. Ohno;B. Seligmann;J. Gallin
通讯作者:
J. Gallin
DOI:
--
发表时间:
1988
期刊:
Laboratory investigation; a journal of technical methods and pathology
影响因子:
--
作者:
Ward,PA;Cunningham,TW;McCulloch,KK;Johnson,KJ
通讯作者:
Johnson,KJ