Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort.
Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort.
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DOI：
10.1021/acs.jproteome.6b01062
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发表时间：
2017-09-01
影响因子：
4.4
通讯作者：
Rinaldi S
中科院分区：
文献类型：
--
作者：
Carayol M;Leitzmann MF;Ferrari P;Zamora-Ros R;Achaintre D;Stepien M;Schmidt JA;Travis RC;Overvad K;Tjønneland A;Hansen L;Kaaks R;Kühn T;Boeing H;Bachlechner U;Trichopoulou A;Bamia C;Palli D;Agnoli C;Tumino R;Vineis P;Panico S;Quirós JR;Sánchez-Cantalejo E;Huerta JM;Ardanaz E;Arriola L;Agudo A;Nilsson J;Melander O;Bueno-de-Mesquita B;Peeters PH;Wareham N;Khaw KT;Jenab M;Key TJ;Scalbert A;Rinaldi S
代谢组学现已广泛用于表征与肥胖等生活方式风险因素相关的代谢表型。本研究的目的是探讨体重指数（BMI）与欧洲癌症与营养前瞻性调查（EPIC）研究中血液样本中测量的145种代谢物的相关性。对来自牛津（英国）队列（EPIC-Oxford）的392名男性和327名对照受试者（肝胆癌巢式病例对照研究（EPIC-Hepatobiliary）的一部分）的血液中的甲硫氨酸进行了测量。测定的代谢物包括氨基酸、酰基肉毒碱、己糖、生物胺、磷脂酰胆碱和鞘磷脂。运行控制潜在混杂因素的线性回归模型和多重检验，以评价代谢物浓度与BMI的相关性。根据BMI变化，EPIC-Oxford和EPIC-肝胆亚队列中分别有40和45种单个代谢物显示出显著差异。在两个子队列中，22种单个代谢物（犬尿氨酸、1种鞘磷脂、谷氨酸和19种磷脂酰胆碱）与BMI相关。目前的研究结果提供了关于欧洲成年人BMI的血液代谢特征的额外知识，这可能有助于确定介导BMI与肥胖相关疾病关系的机制。
Metabolomic is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary sub-cohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both sub-cohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identifying mechanisms mediating the relationship of BMI with obesity-related diseases.
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影响因子：
3.7
作者：
Breier M;Wahl S;Prehn C;Fugmann M;Ferrari U;Weise M;Banning F;Seissler J;Grallert H;Adamski J;Lechner A
通讯作者：
Lechner A
影响因子：
7.7
作者：
Floegel A;Stefan N;Yu Z;Mühlenbruch K;Drogan D;Joost HG;Fritsche A;Häring HU;Hrabě de Angelis M;Peters A;Roden M;Prehn C;Wang-Sattler R;Illig T;Schulze MB;Adamski J;Boeing H;Pischon T
通讯作者：
Pischon T
影响因子：
37.8
作者：
Cheng S;Rhee EP;Larson MG;Lewis GD;McCabe EL;Shen D;Palma MJ;Roberts LD;Dejam A;Souza AL;Deik AA;Magnusson M;Fox CS;O'Donnell CJ;Vasan RS;Melander O;Clish CB;Gerszten RE;Wang TJ
通讯作者：
Wang TJ
影响因子：
7.7
作者：
Hamilton, Marc T.;Hamilton, Deborah G.;Zderic, Theodore W.
通讯作者：
Zderic, Theodore W.
影响因子：
5.8
作者：
Gaudet, Mia M.;Falk, Roni T.;Sherman, Mark E.
通讯作者：
Sherman, Mark E.