Bilateral movement training promotes axonal remodeling of the corticospinal tract and recovery of motor function following traumatic brain injury in mice.
Bilateral movement training promotes axonal remodeling of the corticospinal tract and recovery of motor function following traumatic brain injury in mice.
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DOI：
10.1038/cddis.2013.62
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发表时间：
2013-03-07
影响因子：
9
通讯作者：
中科院分区：
文献类型：
--
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外伤性脑损伤（TBI）导致严重的运动功能损伤，随后的恢复往往是不完整的。康复训练被认为可以促进损伤神经网络的恢复，从而促进功能的恢复。然而，还没有研究评估这种训练在神经重新布线的背景下的效果。本文研究了两种类型的康复训练对小鼠皮质脊髓束（CST）可塑性和运动恢复的影响。我们用挫伤损伤单侧运动皮质，引起对侧偏瘫。损伤后，小鼠执行单一的颗粒到达任务（简单的重复训练）或旋转任务（双侧运动训练）。然后使用多项行为测试来评估前肢运动功能恢复：楼梯、梯子行走、卡佩里尼搬运、单粒和旋转棒测试。TBI+rotarod组在大多数前肢运动任务（楼梯，梯子行走和capellini处理测试）中比仅TBI组表现更好。相比之下，TBI+到达组除了在单粒测试中表现更好。损伤后，生物素化右旋糖酐胺标记的对侧CST在颈脊髓失神经侧形成发芽纤维。这些纤维的数量在TBI+rotarod组中显著增加，而在TBI+到达组中没有增加。这些结果表明，双侧运动训练能有效促进轴突重组和运动功能恢复，而简单的重复训练效果有限。
Traumatic brain injury (TBI) results in severe motor function impairment, and subsequent recovery is often incomplete. Rehabilitative training is considered to promote restoration of the injured neural network, thus facilitating functional recovery. However, no studies have assessed the effect of such trainings in the context of neural rewiring. Here, we investigated the effects of two types of rehabilitative training on corticospinal tract (CST) plasticity and motor recovery in mice. We injured the unilateral motor cortex with contusion, which induced hemiparesis on the contralesional side. After the injury, mice performed either a single pellet-reaching task (simple repetitive training) or a rotarod task (bilateral movement training). Multiple behavioral tests were then used to assess forelimb motor function recovery: staircase, ladder walk, capellini handling, single pellet, and rotarod tests. The TBI+rotarod group performed most forelimb motor tasks (staircase, ladder walk, and capellini handling tests) better than the TBI-only group did. In contrast, the TBI+reaching group did not perform better except in the single pellet test. After the injury, the contralateral CST, labeled by biotinylated dextran amine, formed sprouting fibers into the denervated side of the cervical spinal cord. The number of these fibers was significantly higher in the TBI+rotarod group, whereas it did not increase in the TBI+reaching group. These results indicate that bilateral movement training effectively promotes axonal rewiring and motor function recovery, whereas the effect of simple repetitive training is limited.
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影响因子：
5.3
作者：
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DOI：
10.1016/0003-9993(94)90108-2
发表时间：
1994-08-01
影响因子：
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通讯作者：
OLSEN, TS