Enterovirus A71 Proteins: Structure and Function.

Enterovirus A71 Proteins: Structure and Function.
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肠道病毒 A71 蛋白:结构和功能

DOI:
10.3389/fmicb.2018.00286
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发表时间:
2018
影响因子:
5.2
通讯作者:
Mao L
Mao L
中科院分区:
生物学2区
文献类型:
--
作者:
Yuan J;Shen L;Wu J;Zou X;Gu J;Chen J;Mao L

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肠道病毒A71 (EV-A71)感染已成为对全球公共卫生的严重威胁。它是婴幼儿手足口病(HFMD)的主要原因之一。EV-A71还可感染中枢神经系统(CNS)并诱发多种神经系统并发症,如脑干脑炎、无菌性脑膜炎和急性弛缓性麻痹,甚至死亡。病毒蛋白在EV-A71感染中起关键作用。最近的许多研究都讨论了EV-A71蛋白的结构和功能,报告的发现肯定会有助于疫苗和治疗方法的开发。本文就EV-A71蛋白的结构和功能的研究进展作一综述。现有文献可为详细研究EV-A71感染的发病机制提供依据。
Enterovirus A71 (EV-A71) infection has grown to become a serious threat to global public health. It is one of the major causes of hand, foot, and mouth disease (HFMD) in infants and young children. EV-A71 can also infect the central nervous system (CNS) and induce diverse neurological complications, such as brainstem encephalitis, aseptic meningitis, and acute flaccid paralysis, or even death. Viral proteins play a crucial role in EV-A71 infection. Many recent studies have discussed the structure and function of EV-A71 proteins, and the findings reported will definitely aid the development of vaccines and therapeutic approaches. This article reviews the progress in the research on the structure and function of EV-A71 proteins. Available literature can provide a basis for studying the pathogenesis of EV-A71 infection in detail.
DOI: 10.1371/journal.pone.0148693
发表时间: 2016
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影响因子: 3.7
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