Altered inhibition of dentate granule cells during spatial learning in an exploration task
Altered inhibition of dentate granule cells during spatial learning in an exploration task
复制标题
在探索任务的空间学习过程中改变齿状颗粒细胞的抑制
作者：
EI Moser
要调查在何种程度上抑制性中间神经元控制脉冲流通过齿状回在探索任务中的空间学习，齿状场电位记录在响应成对刺激的穿孔路径，而大鼠休息或探索。颗粒细胞的复发性抑制被测量为当第一个波形中存在群体尖峰时第二个波形的减少。群体尖峰和场EPSP（fEPSP）被抑制在刺激间隔短于约40毫秒。在探索和休息（参考）条件下，在相等的大脑温度下记录的电位之间观察到一致的差异。在探索期间，与对第一（条件反射）刺激具有类似反应的参考电位相比，第二（测试）波形的fEPSP进一步降低。只有当第一个脉冲引起种群尖峰时，才观察到这种减少。与具有相似fEPSP斜率的参考电位相比，第二波形的群体尖峰被促进。这些观察结果表明，勘探耦合到增加的抑制上的穿通通路终端或树突的颗粒细胞，而抑制上的胞体减少。这两种现象不相关，并遵循不同的时间进程。fEPSP的抑制逐渐衰减，虽然它仍然存在于15分钟，而促进的群体尖峰是稳定的。总之，这些变化可能涉及不同的中间神经元群体，可能会集中和放大来自内嗅皮层的传入信号。
To investigate the extent to which inhibitory interneurons control impulse flow through the dentate gyrus during spatial learning in an exploration task, dentate field potentials were recorded in response to paired stimulation of the perforant path while rats rested or explored. Recurrent inhibition of the granule cells was measured as the reduction of the second waveform when a population spike was present in the first. Both the population spike and the field EPSP (fEPSP) were suppressed at interstimulus intervals shorter than approximately 40 msec. Consistent differences were observed between potentials recorded at equivalent brain temperature in the exploration and resting (reference) conditions. During exploration, the fEPSP of the second (test) waveform was reduced further compared with reference potentials with a similar response to the first (conditioning) stimulus. This reduction was observed only when the first pulse elicited a population spike. The population spike of the second waveform was facilitated compared with reference potentials with similar fEPSP slopes. These observations suggest that exploration is coupled to increased inhibition on the perforant-path terminals or the dendrites of the granule cells, whereas the inhibition on the somata is decreased. The two phenomena were not correlated and followed different time courses. The suppression of the fEPSP decayed gradually, although it was still present at 15 min, whereas the facilitation of the population spike was stable. Together, these changes, which likely involve different populations of interneurons, may focus and amplify incoming signals from the entorhinal cortex.
大鼠海马结构中生长抑素免疫反应性神经元的起源时间。
影响因子：
2.9
作者：
Rapp,PR;Amaral,DG
通讯作者：
Amaral,DG
影响因子：
56.9
作者：
ZALUTSKY, RA;NICOLL, RA
通讯作者：
NICOLL, RA