FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons.
FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons.
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DOI：
10.1016/j.nbd.2008.09.019
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发表时间：
2009-01
影响因子：
6.1
通讯作者：
Yamada, Kelvin A.
中科院分区：
文献类型：
--
作者：
Shakkottai, Vikram G.;Xiao, Maolei;Xu, Lin;Wong, Michael;Nerbonne, Jeanne M.;Ornitz, David M.;Yamada, Kelvin A.
关键词：
A missense mutation in the fibroblast growth factor 14 (FGF14) gene underlies SCA27, an autosomal dominant spinocerebellar ataxia in humans. Mice with a targeted disruption of the Fgf14 locus (Fgf14−/−) develop ataxia resembling human SCA27. We tested the hypothesis that loss of FGF14 affects the firing properties of Purkinje neurons, which play an important role in motor control and coordination. Current clamp recordings from Purkinje neurons in cerebellar slices revealed attenuated spontaneous firing in Fgf14−/− neurons. Unlike in the wild type animals, more than 80% of Fgf14−/− Purkinje neurons were quiescent and failed to fire repetitively in response to depolarizing current injections. Immunohistochemical examination revealed reduced expression of Nav1.6 protein in Fgf14−/− Purkinje neurons. Together, these observations suggest that FGF14 is required for normal Nav1.6 expression in Purkinje neurons, and that the loss of FGF14 impairs spontaneous and repetitive firing in Purkinje neurons by altering the expression of Nav1.6 channels.
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影响因子：
2.5
作者：
Afshari, FS;Ptak, K;Raman, IM
通讯作者：
Raman, IM
影响因子：
5.3
作者：
Laezza, Fernanda;Gerber, Benjamin R.;Nerbonne, Jeanne M.
通讯作者：
Nerbonne, Jeanne M.
DOI：
10.1073/pnas.93.18.9850
发表时间：
1996-09-03
影响因子：
11.1
作者：
Smallwood, PM;MunozSanjuan, I;Nathans, J
通讯作者：
Nathans, J
影响因子：
5.5
作者：
Edgerton, JR;Reinhart, PH
通讯作者：
Reinhart, PH
影响因子：
2.5
作者：
Levin, Stephen I.;Khaliq, Zayd M.;Meisler, Miriam H.
通讯作者：
Meisler, Miriam H.