Serum Sp17 Autoantibody Serves as a Potential Specific Biomarker in Patients with SAPHO Syndrome.
Serum Sp17 Autoantibody Serves as a Potential Specific Biomarker in Patients with SAPHO Syndrome.
复制标题
血清 Sp17 自身抗体可作为 SAPHO 综合征患者的潜在特异性生物标志物。
DOI：
10.1007/s10875-020-00937-w
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发表时间：
2021-04
影响因子：
9.1
通讯作者：
He W
中科院分区：
文献类型：
--
作者：
You H;Dang G;Lu B;Zhang S;Li C;Wang L;Hu Y;Chen H;Zhang J;He W
SAPHO（滑膜炎、痤疮、脓疱病、骨质增生和骨炎）综合征在肌肉骨骼和皮肤表现上表现出广泛的变异性，因此由于缺乏特异性标志物，在临床上被低估和误诊。在这项研究中，我们的目的是通过筛选血清自身抗体SAPHO患者与17 K人类全蛋白质组芯片，以确定特定的生物标志物。血清抗Sp17自身抗体被鉴定并证实是SAPHO综合征患者的特异性生物标志物。事实上，与非活动性疾病患者和健康对照组相比，活动性SAPHO患者的抗Sp17自身抗体水平显著升高（P < 0.05）。此外，在活动性SAPHO患者中，血清抗Sp17自身抗体水平与血清超敏C反应蛋白（hsCRP）、红细胞沉降率（ESR）和β-交联蛋白（β-CTx）水平相关。此外，抗Sp17自身抗体水平显着下降后，抗炎治疗帕米膦酸二钠，下调hsCRP和ESR水平的活动性SAPHO患者。因此，血清中抗Sp17自身抗体水平可能作为诊断SAPHO综合征或监测疾病状态的特异性生物标志物。在线版本包含补充材料，可通过10.1007/s10875-020-00937-w获得。
SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome shows a wide variability in musculoskeletal and cutaneous manifestations, and it is therefore underrecognized and misdiagnosed in the clinic due to a lack of specific markers. In this study, we aimed to identify specific biomarkers by screening serum autoantibodies in SAPHO patients with a 17K human whole-proteome microarray. The serum anti-Sp17 autoantibody was identified and verified to be a specific biomarker in patients with SAPHO syndrome. Indeed, the level of the anti-Sp17 autoantibody was significantly increased in patients with active SAPHO compared to patients with an inactive disease and healthy controls (P < 0.05). Additionally, serum anti-Sp17 autoantibody levels correlated with those of serum hypersensitive C-reactive protein (hsCRP), the erythrocyte sedimentation rate (ESR), and β-crosslaps (β-CTx) in patients with active SAPHO disease. Moreover, anti-Sp17 autoantibody levels were markedly decreased after anti-inflammatory treatment with pamidronate disodium, which downregulated levels of hsCRP and ESR in patients with active SAPHO. Thus, serum levels of the anti-Sp17 autoantibody might serve as a specific biomarker for the diagnosis of SAPHO syndrome or for monitoring the disease status. The online version contains supplementary material available at 10.1007/s10875-020-00937-w.
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