The evolution of a disparity decision in human visual cortex.
The evolution of a disparity decision in human visual cortex.
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DOI：
10.1016/j.neuroimage.2014.01.055
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发表时间：
2014-05-15
期刊：
影响因子：
5.7
通讯作者：
Norcia AM
中科院分区：
文献类型：
--
作者：
Cottereau BR;Ales JM;Norcia AM
我们在人类中使用fMRI知情的EEG源成像来表征在识别任务期间皮质反应的动态。在一个明确定义的目标出现后，在一个扩展的皮质网络中发现了决策相关的活动，该网络包括几个枕叶感兴趣区域（ROI）：V4、V3A、hMT+和枕外侧复合体（V4）。通过使用响应锁定分析，我们能够确定相对于受试者的行为响应的ROI网络中的时序关系。选择相关活动首先出现在V4 ROI中，大约在按钮按下前200 ms，然后出现在V3A ROI中。在V4 ROI中的响应的建模表明，该区域提供了对视差辨别的早期贡献。按下按钮后，在ROI V4、V3A、HMT和hMT+中也发现了选择相关反应。在视觉皮层之外，在按下按钮之前，在额叶和颞极发现了与选择相关的活动。通过将fMRI知情EEG源成像的空间分辨率与在决定的行为表现之前、期间和之后发生的神经活动的能力相结合，我们的研究首次将不同的功能角色分配给基于视差的感知决定中涉及的纹外ROI，深度的主要线索。
We used fMRI-informed EEG source-imaging in humans to characterize the dynamics of cortical responses during a disparity-discrimination task. After the onset of a disparity-defined target, decision-related activity was found within an extended cortical network that included several occipital regions of interest (ROIs): V4, V3A, hMT+ and the Lateral Occipital Complex (LOC). By using a response-locked analysis, we were able to determine the timing relationships in this network of ROIs relative to the subject's behavioral response. Choice-related activity appeared first in the V4 ROI almost 200 ms before the button press and then subsequently in the V3A ROI. Modeling of the responses in the V4 ROI suggests that this area provides an early contribution to disparity discrimination. Choice-related responses were also found after the button-press in ROIs V4, V3A, LOC and hMT+. Outside the visual cortex, choice-related activity was found in the frontal and temporal pole before the button-press. By combining the spatial resolution of fMRI-informed EEG source imaging with the ability to sort out neural activity occurring before, during and after the behavioral manifestation of the decision, our study is the first to assign distinct functional roles to the extra-striate ROIs involved in perceptual decisions based on disparity, the primary cue for depth.
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影响因子：
2.5
作者：
Cottereau，Benoit R.;McKee，Suzanne P.;Norcia，Anthony M.
通讯作者：
Norcia，Anthony M.
影响因子：
3
作者：
Im, Chang-Hwan;Gururajan, Arvind;He, Bin
通讯作者：
He, Bin
DOI：
10.1523/jneurosci.3795-10.2011
发表时间：
2011-01-19
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cottereau BR;McKee SP;Ales JM;Norcia AM
通讯作者：
Norcia AM
影响因子：
25
作者：
Huk, AC;Heeger, DJ
通讯作者：
Heeger, DJ
影响因子：
5.3
作者：
Donner, Tobias H.;Sagi, Dov;Heeger, David J.
通讯作者：
Heeger, David J.