Decreased expression of microRNA-124 is an independent unfavorable prognostic factor for patients with breast cancer.
Decreased expression of microRNA-124 is an independent unfavorable prognostic factor for patients with breast cancer.
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对于乳腺癌患者而言，microRNA-124的表达降低是独立的不利预后因素。
DOI：
10.1186/s13000-015-0257-5
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发表时间：
2015-04-29
影响因子：
2.6
通讯作者：
Zhang LM
中科院分区：
文献类型：
--
作者：
Dong LL;Chen LM;Wang WM;Zhang LM
MicroRNA-124(miR-124)在乳腺癌中表达下调。然而，其在乳腺癌中的临床意义和预后价值尚未得到广泛研究。采用实时定量聚合酶链式反应技术检测133例乳腺癌患者组织中miR-124的表达水平。并分析miR-124水平与患者临床病理因素的相关性。生存分析和COX比例风险回归分析确定miR-124表达水平与患者预后的相关性。实时定量聚合酶链式反应分析显示，乳腺癌组织中miR-124的表达低于癌旁正常乳腺组织(0.39 ± 0.16vs.1.00 ± 0.39；P <； 0.05)。MiR-124低表达与肿瘤分期(P = 0.011)、淋巴结转移(P = 0.012)和分化程度低(P = 0.023)显著相关。低表达乳腺癌患者的总生存期明显短于高表达乳腺癌患者(63.8%vs.35.2%，P = 0.03)。用COX比例风险模型对预后因素进行多因素分析，证实miR124低表达是乳腺癌预后不良的独立预测因素(HR = 3.16，95%CI：1.79~9.13，P = 0.017)。这些结果证明miR-124的低表达可能与乳腺癌患者的肿瘤进展和预后不良有关。本文的虚拟幻灯片(S)可在此处找到：http://www.diagnosticpathology.diagnomx.eu/vs/3752603721493544
MicroRNA-124 (miR-124) has been reported to be downregulated in breast cancer. However, its clinical significance and prognostic value in breast cancer have not been extensively studied. The tissue expression levels of miR-124 were measured using quantitative real-time PCR in 133 breast cancer patients. The correlation between the miR-124 levels and the clinicopathological factors of the patients was also analyzed. Survival and Cox proportional-hazards regression analyses were performed to determine the correlation between miR-124 expression levels and prognosis in the patients. Quantitative real-time PCR analysis showed that miR-124 had lower expression in breast cancer specimens than that in matched adjacent normal breast tissues (0.39 ± 0.16 vs. 1.00 ± 0.39; P < 0.05). Low miR-124 expression level was significantly associated with advanced TNM stage (P = 0.011), lymph node metastasis (P = 0.012), and poorer pathological differentiation (P = 0.023). A significant difference was found that breast cancer patients with low miR-124 expression level had distinctly shorter overall survival than patients with high miR-124 expression level (63.8% vs. 35.2%, P = 0.03). Furthermore, multivariate analysis of the prognosis factors with a Cox proportional hazards model confirmed that low miR-124 expression was a significant independent predictor of poor survival in breast cancer (HR = 3.16, 95% CI: 1.79-9.13, P = 0.017). These findings proved that the decreased expression of miR-124 might be associated with tumor progression and poor prognosis in patients with breast cancer. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3752603721493544
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