Cholesterol sulfate imaging in human prostate cancer tissue by desorption electrospray ionization mass spectrometry.
Cholesterol sulfate imaging in human prostate cancer tissue by desorption electrospray ionization mass spectrometry.
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DOI：
10.1021/ac9029482
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发表时间：
2010-05-01
影响因子：
7.4
通讯作者：
Cooks, R. Graham
中科院分区：
文献类型：
--
作者：
Eberlin, Livia S.;Dill, Allison L.;Costa, Anthony B.;Ifa, Demian R.;Cheng, Liang;Masterson, Timothy;Koch, Michael;Ratliff, Timothy L.;Cooks, R. Graham
发展快速区分癌性和非肿瘤性组织的方法是疾病诊断的重要目标。为此，解吸电喷雾离子化质谱（ESIMS）成像应用于分析68例人前列腺癌和正常组织的薄组织切片的脂质谱。通过独立的组织病理学检查确定组织切片的疾病状态。硫酸胆固醇被鉴定为一种分化化合物，几乎仅在癌组织中发现，包括含有癌前病变的组织。前列腺组织中硫酸胆固醇的存在可能作为前列腺癌诊断的工具，尽管需要通过更大和更多样化的队列进行确认，并与临床结局数据相关。
Development of methods for rapid distinction between cancerous and non-neoplastic tissues is an important goal in disease diagnosis. To this end, desorption electrospray ionization mass spectrometry (DESI-MS) imaging was applied to analyze the lipid profiles of thin tissue sections of 68 samples of human prostate cancer and normal tissue. The disease state of the tissue sections was determined by independent histopathological examination. Cholesterol sulfate was identified as a differentiating compound, found almost exclusively in cancerous tissues including tissue containing precancerous lesions. The presence of cholesterol sulfate in prostate tissues might serve as a tool for prostate cancer diagnosis although confirmation through larger and more diverse cohorts and correlations with clinical outcome data is needed.
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影响因子：
2.3
作者：
Walch, Axel;Rauser, Sandra;Deininger, Soeren-Oliver;Hoefler, Heinz
通讯作者：
Hoefler, Heinz
影响因子：
11.5
作者：
Titus, MA;Schell, MJ;Mohler, JL
通讯作者：
Mohler, JL
影响因子：
11.2
作者：
Glunde, K;Jie, C;Bhujwalla, ZM
通讯作者：
Bhujwalla, ZM
影响因子：
10.3
作者：
Migita, Toshiro;Ruiz, Stacey;Loda, Massimo
通讯作者：
Loda, Massimo
影响因子：
16.6
作者：
Schaefer, Karl-Christian;Denes, Julia;Takats, Zoltan
通讯作者：
Takats, Zoltan