Cellular and humoral immunity in arthritis are profoundly influenced by the interaction between cigarette smoke effects and host HLA-DR and DQ genes.
Cellular and humoral immunity in arthritis are profoundly influenced by the interaction between cigarette smoke effects and host HLA-DR and DQ genes.
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DOI：
10.1016/j.clim.2014.02.002
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Taneja V
中科院分区：
文献类型：
--
作者：
Vassallo R;Luckey D;Behrens M;Madden B;Luthra H;David C;Taneja V
携带DRB 1 *0401的吸烟者患严重血清阳性RA的风险增加。为了确定香烟烟雾（CS）如何在诱导RA相关自身免疫中与宿主遗传因素相互作用，我们使用了携带RA易感HLA基因DR4和DQ 8的转基因小鼠，但缺乏所有内源性小鼠II类分子。香烟烟雾暴露增强肽基精氨酸脱亚胺酶（PAD）酶的表达，并增强免疫反应的瓜氨酸胶原蛋白和波形蛋白。在这里，我们第一次表明，DQ分子可以提出瓜氨酸肽比天然肽更有效。有趣的是，CS暴露抑制DRB 1 *0401小鼠中胶原诱导的关节炎（CIA），尽管先天免疫应答增强。另一方面，CS暴露加重了DQ 8小鼠的CIA，这伴随着肺中Th17基因转录物表达的增加。这些观察结果表明，香烟烟雾促进抗原特异性自身免疫，这是由宿主遗传因素的深刻影响。
Individuals carrying DRB1*0401 who smoke cigarettes are at an increased risk of developing severe seropositive RA. To determine how cigarette smoke (CS) interacts with host genetic factors in the induction of RA-associated autoimmunity, we used transgenic mice carrying the RA-susceptible HLA genes DR4 and DQ8, but lacking all endogenous murine class II molecules. Cigarette smoke exposure augmented peptidylarginine deiminase (PAD) enzyme expression, and enhanced immune responses to citrullinated collagen and vimentin. Here we show for the first time that DQ molecules can present citrullinated peptides much more efficiently than native peptides. Interestingly, CS exposure suppressed collagen-induced arthritis (CIA) in DRB1*0401 mice although innate immune response was enhanced. On the other hand, CS exposure exacerbated CIA in DQ8 mice, which was accompanied by an increased expression of Th17 gene transcripts in lungs. These observations suggest that cigarette smoke promotes antigen-specific autoimmunity that is profoundly influenced by host genetic factors.
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影响因子：
4.4
作者：
Taneja, V;Taneja, N;David, CS
通讯作者：
David, CS
DOI：
10.1073/pnas.96.18.10338
发表时间：
1999-08-31
影响因子：
11.1
作者：
Madsen, L;Labrecque, N;Fugger, L
通讯作者：
Fugger, L
影响因子：
13.6
作者：
Szodoray, Peter;Szabo, Zoltan;Szekanecz, Zoltan
通讯作者：
Szekanecz, Zoltan
影响因子：
12.8
作者：
Behrens, Marshall;Trejo, Theodore;Taneja, Veena
通讯作者：
Taneja, Veena
白介素13是B细胞刺激因子。
影响因子：
15.3
作者：
Defrance, T;Carayon, P;Billian, G;Guillemot, J C;Minty, A;Caput, D;Ferrara, P
通讯作者：
Ferrara, P