Recent insights into atopic dermatitis and implications for management of infectious complications.
Recent insights into atopic dermatitis and implications for management of infectious complications.
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DOI:
10.1016/j.jaci.2009.11.027
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发表时间:
2010-01
影响因子:
14.2
通讯作者:
Leung, Donald Y. M.
中科院分区:
文献类型:
--
作者:
Boguniewicz, Mark;Leung, Donald Y. M.
关键词:
Atopic dermatitis is a common, complex disease that frequently follows a chronic, relapsing course and impacts the quality of life of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Patients with AD have a unique predisposition to colonization or infection by a number of microbial organisms, most notably Staphylococcus aureus and herpes simpex virus. A multi-pronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes.
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