Recent insights into atopic dermatitis and implications for management of infectious complications.

Recent insights into atopic dermatitis and implications for management of infectious complications.
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DOI:
10.1016/j.jaci.2009.11.027
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发表时间:
2010-01
影响因子:
14.2
通讯作者:
Leung, Donald Y. M.
Leung, Donald Y. M.
中科院分区:
医学1区
文献类型:
--
作者:
Boguniewicz, Mark;Leung, Donald Y. M.

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特应性皮炎是一种常见、复杂的疾病,通常呈慢性、复发性病程,严重影响患者及其家庭的生活质量。对 AD 病理生理学的新见解表明,表皮结构异常与免疫失调相结合发挥着重要作用。 AD 患者具有独特的易受多种微生物定植或感染的倾向,尤其是金黄色葡萄球菌和单纯疱疹病毒。为了提高成功结果的可能性,有必要采取多管齐下的方法来治愈或保护皮肤屏障并解决免疫失调问题。
Atopic dermatitis is a common, complex disease that frequently follows a chronic, relapsing course and impacts the quality of life of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Patients with AD have a unique predisposition to colonization or infection by a number of microbial organisms, most notably Staphylococcus aureus and herpes simpex virus. A multi-pronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes.
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