Preliminary Volumetric Calculation of the Mucosal Surface in the Nares of Lambs Using a Segmentation of Computed Tomographic Images.
Preliminary Volumetric Calculation of the Mucosal Surface in the Nares of Lambs Using a Segmentation of Computed Tomographic Images.
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DOI：
10.3389/fvets.2020.620647
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发表时间：
2020
影响因子：
3.2
通讯作者：
Berner D
中科院分区：
文献类型：
--
作者：
Teeling KP;Werling D;Berner D
鼻内疫苗接种在人类和动物医学中都变得越来越重要，因为它可以产生局部的IgA免疫反应，而非肠外疫苗接种。这种局部IgA反应在减少潜在宿主粘膜表面的病原体负荷方面更有效。成功的鼻腔疫苗接种的一个先决条件是需要了解雾化疫苗的分布模式，这需要了解鼻腔的体积以及粘膜表面积。反刍动物鼻腔的确切粘膜表面积尚未被研究过。本概念研究的目的是提供一种新的体积渲染方法的详细分解，该方法可用于从计算机层析图像中计算反刍动物鼻腔的体积和粘膜表面积。Seg 3D程序被用于对一个9个月大的羔羊头的CT扫描进行半自动分割。采用阈值分割和人工分割相结合的方法对羔羊鼻腔进行选择。分割过程产生了一个体积渲染，用于计算羔羊鼻腔的表面积和体积，分割过程对羔羊的每一个鼻孔重复。每个鼻孔粘膜表面的表面积约为448 cm2，体积约为45 cm3。本研究中描述的方法成功地使用体积渲染法计算了羔羊鼻子的体积和表面积。
Intranasal vaccinations are becoming more important in both human and animal medicine to generate a localized IgA immune response not seen with parenteral vaccinations. This localized IgA response is more effective at reducing pathogen load on the mucosal surface of a potential host. One prerequisite for a successful nasal vaccination is the need to understand the distribution pattern of the nebulized vaccine, which requires an understanding the volume of the nares as well as the mucosal surface area. The exact mucosal surface area of ruminant nares has not yet been investigated. The aim of this concept study is to provide a detailed breakdown of a new method of volumetric rendering that can be used to calculate the volume and mucosal surface area of ruminant nares from computed tomographic images. The program Seg 3D was used to perform semi-automatic segmentation of a CT scan of a 9-month-old lamb head. Threshold segmentation and manual segmentation were used in combination to select the lamb's nasal cavity. The segmentation process yielded a volumetric rendering that was used to calculate the surface area and volume of the lamb's nasal cavity, with the segmentation process was repeated for each individual side of the lamb's nares. The surface area of the mucosal surface of each nostril is approximately 448 cm2, and the volume is approximately 45 cm3. The methodology described in this study successfully calculated the volume and surface area of a lamb's nares using volumetric rendering.
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影响因子：
3.7
作者：
Wu, HY;Nguyen, HH;Russell, MW
通讯作者：
Russell, MW
影响因子：
2.6
作者：
Brinkschulte M;Bienert-Zeit A;Lüpke M;Hellige M;Ohnesorge B;Staszyk C
通讯作者：
Staszyk C
DOI：
10.1111/vru.12080
发表时间：
2013-11-01
期刊：
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
影响因子：
--
作者：
Brinkschulte, Markus;Bienert-Zeit, Astrid;Ohnesorge, Bernhard
通讯作者：
Ohnesorge, Bernhard
影响因子：
1.8
作者：
Shewen, P. E.;Carrasco-Medina, L.;Hodgins, D. C.
通讯作者：
Hodgins, D. C.
DOI：
10.1007/s11548-006-0041-9
发表时间：
2006-08-01
影响因子：
3
作者：
Shi, Hongjian;Scarfe, William C.;Farman, Allan G.
通讯作者：
Farman, Allan G.