Rapidly expanding genetic diversity and host range of the Circoviridae viral family and other Rep encoding small circular ssDNA genomes.
Rapidly expanding genetic diversity and host range of the Circoviridae viral family and other Rep encoding small circular ssDNA genomes.
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DOI：
10.1016/j.virusres.2011.11.021
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发表时间：
2012-03
期刊：
影响因子：
5
通讯作者：
Li, Linlin
中科院分区：
文献类型：
--
作者：
Delwart, Eric;Li, Linlin
编码滚环复制起始蛋白（Rep）的许多圆环病毒和远缘环状DNA病毒的基因组已从哺乳动物、鱼类、昆虫和植物（双生病毒和纳米病毒）、人类和动物粪便、藻类细胞和各种环境样品的组织中进行了表征。本文综述了圆环病毒科中一个新的属--圆环病毒的基因组结构、系统发育关系和初步流行研究。还鉴定了整合在哺乳动物、青蛙、矛状幼体、甲壳类动物、螨、腹足类动物、蛔虫、扁形动物、水螅动物、原生动物、陆生植物、真菌、藻类和植原体细菌及其质粒的染色体上的病毒化石rep序列，反映了它们过去的宿主范围。一个古老的起源与REP编码单链小环状基因组的病毒，早于真核生物的多样化，进行了讨论。许多最近描述的含REP的环状基因组的细胞宿主和致病性仍有待确定。单细胞和多细胞真核生物的病毒组的未来研究可能会进一步扩展已知的多样性和宿主范围的小rep含有环状病毒基因组。
The genomes of numerous circoviruses and distantly related circular DNA viruses encoding a rolling circle replication initiator protein (Rep) have been characterized from the tissues of mammals, fish, insects, and plants (geminivirus and nanovirus), human and animal feces, in an algae cell, and in diverse environmental samples. We review the genome organization, phylogenetic relationships and initial prevalence studies of cycloviruses, a proposed new genus in the Circoviridae family. Viral fossil rep sequences were also identified integrated on the chromosomes of mammals, frogs, lancelets, crustaceans, mites, gastropods, roundworms, placozoans, hydrozoans, protozoans, land plants, fungi, algae, and phytoplasma bacterias and their plasmids, reflecting their past host range. An ancient origin for viruses with rep-encoding single stranded small circular genomes, predating the diversification of eukaryotes, is discussed. The cellular hosts and pathogenicity of many recently described rep-containing circular genomes remain to be determined. Future studies of the virome of single cell and multi-cellular eukaryotes are likely to further extend the known diversity and host-range of small rep-containing circular viral genomes.
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