PROMALS web server for accurate multiple protein sequence alignments.
PROMALS web server for accurate multiple protein sequence alignments.
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DOI:
10.1093/nar/gkm227
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发表时间:
2007-07
影响因子:
14.9
通讯作者:
Grishin NV
中科院分区:
文献类型:
--
作者:
Pei J;Kim BH;Tang M;Grishin NV
Multiple sequence alignments are essential in homology inference, structure modeling, functional prediction and phylogenetic analysis. We developed a web server that constructs multiple protein sequence alignments using PROMALS, a progressive method that improves alignment quality by using additional homologs from PSI-BLAST searches and secondary structure predictions from PSIPRED. PROMALS shows higher alignment accuracy than other advanced methods, such as MUMMALS, ProbCons, MAFFT and SPEM. The PROMALS web server takes FASTA format protein sequences as input. The output includes a colored alignment augmented with information about sequence grouping, predicted secondary structures and positional conservation. The PROMALS web server is available at: http://prodata.swmed.edu/promals/
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DOI:
10.1073/pnas.89.22.10915
发表时间:
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影响因子:
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作者:
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通讯作者:
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影响因子:
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