Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen.
Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen.
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DOI：
10.1016/j.celrep.2021.108861
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发表时间：
2021-03-16
期刊：
影响因子：
8.8
通讯作者：
Alarcón B
中科院分区：
文献类型：
--
作者：
Boccasavia VL;Bovolenta ER;Villanueva A;Borroto A;Oeste CL;van Santen HM;Prieto C;Alonso-López D;Diaz-Muñoz MD;Batista FD;Alarcón B
T细胞与专职抗原呈递细胞（APC）形成免疫突触，导致T细胞活化和从APC的质膜获得肽抗原-MHC（pMHC）复合物。它们本身也成为APC。我们研究了由CD 4 T细胞进行的T-T细胞抗原呈递的功能结果，发现抗原呈递T细胞（Tpres）主要分化为调节性T细胞（Treg），而由Tpres细胞刺激的T细胞主要分化为Th 17促炎细胞。使用缺乏pMHC摄取的T细胞的小鼠，我们表明，T-T抗原呈递是重要的实验性自身免疫性脑炎和Th 17细胞分化的发展在体内。通过改变专业APC：T细胞比例，我们可以在体外和体内调节Treg与Th 17的分化，这表明T-T抗原呈递是抗原缺乏条件下促炎反应的基础。CD 4 T细胞摄取抗原/MHC复合物并将其呈递给同源T细胞在T-T细胞抗原呈递后，应答T细胞分化为Th 17 T-T抗原呈递是自身免疫和病毒感染中Th 17产生的基础抗原的缺乏导致Th 17分化，而抗原的丰富导致Treg Boccasavia et al.显示T细胞从专职抗原呈递细胞获得抗原/MHC，并将其自身转化为具有相同抗原特异性其它T细胞的呈递细胞。这种T-T抗原呈递导致应答T细胞分化为介导自身免疫和对病毒感染的应答的Th 17
T cells form immunological synapses with professional antigen-presenting cells (APCs) resulting in T cell activation and the acquisition of peptide antigen-MHC (pMHC) complexes from the plasma membrane of the APC. They thus become APCs themselves. We investigate the functional outcome of T-T cell antigen presentation by CD4 T cells and find that the antigen-presenting T cells (Tpres) predominantly differentiate into regulatory T cells (Treg), whereas T cells that have been stimulated by Tpres cells predominantly differentiate into Th17 pro-inflammatory cells. Using mice deficient in pMHC uptake by T cells, we show that T-T antigen presentation is important for the development of experimental autoimmune encephalitis and Th17 cell differentiation in vivo. By varying the professional APC:T cell ratio, we can modulate Treg versus Th17 differentiation in vitro and in vivo, suggesting that T-T antigen presentation underlies proinflammatory responses in conditions of antigen scarcity. CD4 T cells take up antigen/MHC complexes and present them to cognate T cells After T-T cell antigen presentation, responding T cells differentiate into Th17 T-T antigen presentation underlies Th17 generation in autoimmunity and viral infection Scarcity of antigen leads to Th17 differentiation, whereas abundance leads to Treg Boccasavia et al. show that T cells acquire antigen/MHC from professional antigen-presenting cells and convert themselves into presenting cells for other T cells of the same antigen specificity. Such T-T antigen presentation results in differentiation of the responding T cells into Th17 that mediate autoimmunity and responses to viral infections
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影响因子：
--
作者：
Cunningham EC;Sharland AF;Bishop GA
通讯作者：
Bishop GA
DOI：
10.1084/jem.191.7.1137
发表时间：
2000-04-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hwang I;Huang JF;Kishimoto H;Brunmark A;Peterson PA;Jackson MR;Surh CD;Cai Z;Sprent J
通讯作者：
Sprent J
TC21和RHOG GTPase依赖性吞噬作用介导了免疫突触的T细胞受体内在化。
影响因子：
32.4
作者：
Martínez-Martín N;Fernández-Arenas E;Cemerski S;Delgado P;Turner M;Heuser J;Irvine DJ;Huang B;Bustelo XR;Shaw A;Alarcón B
通讯作者：
Alarcón B
影响因子：
4.4
作者：
Hudrisier, D;Riond, J;Joly, E
通讯作者：
Joly, E
影响因子：
7.3
作者：
Dhainaut M;Moser M
通讯作者：
Moser M