Seizure control in patients with idiopathic generalized epilepsies: EEG determinants of medication response.
Seizure control in patients with idiopathic generalized epilepsies: EEG determinants of medication response.
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DOI：
10.1016/j.yebeh.2010.02.005
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Privitera MD
中科院分区：
文献类型：
--
作者：
Szaflarski JP;Lindsell CJ;Zakaria T;Banks C;Privitera MD
In a minority of patients with IGEs, seizures continue despite appropriate treatment. We sought to determine the clinical and EEG factors associated with medication response in these patients. All patients with IGEs evaluated by epilepsy specialists between 11/17/08 and 11/16/09 were included. We collected information on seizure freedom (dependent variable), EEG asymmetries, response to valproic acid (VPA), MRI characteristics, medication use, demographic information and seizure history (predictors). We identified 322 patients with IGEs; 45 (14%) were excluded from analyses because of either always having normal EEG (N = 26), lack of any EEG data (N = 3) or medication non-compliance (N = 26). JME patients were more likely to respond to VPA when compared to other IGE patients, and VPA response was associated with seizure freedom. When EEG characteristics were considered, presence of any focal EEG abnormalities (focal slowing, focal epileptiform discharges or both) was associated with decreased odds of seizure-freedom. These findings suggest that IGE patients with poor seizure control may have atypical IGE with possibly focal, e.g., frontal rather than thalamic onset.
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