Spatiotemporal dynamics of high-gamma activities during a 3-stimulus visual oddball task.

Spatiotemporal dynamics of high-gamma activities during a 3-stimulus visual oddball task.
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DOI:
10.1371/journal.pone.0059969
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发表时间:
2013
期刊:
影响因子:
3.7
通讯作者:
Kawashima R
Kawashima R
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Akimoto Y;Kanno A;Kambara T;Nozawa T;Sugiura M;Okumura E;Kawashima R

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虽然许多研究已经研究了自上而下和自下而上注意的神经基础,但它仍然需要在时间和空间上进行细化。我们使用脑磁图来研究高伽马(52-100赫兹)活动在自上而下和自下而上视觉注意过程中的时空动态,旨在扩展功能磁共振成像和事件相关电位研究的结果。14名受试者完成了一项3刺激视觉古怪任务,其中包括不常见的非目标刺激和目标刺激。在靶区和非靶区的不同时间窗内,我们在左侧额中回、左顶内沟、左丘脑和视觉区域发现了与高伽马事件相关的同步。我们还发现,在目标条件下,在300-400ms的高伽马频段,左侧顶内沟和右侧额中回之间,以及在150-450ms的theta频段,左侧丘脑和左额中回之间的想象一致性增强。此外,左侧额中回与左侧顶内沟、左侧额中回与右侧额中回之间的高伽马想象相干性的强度,以及左侧丘脑的高伽马能量预测了目标探测反应时间的不同受试者之间的差异。这一来源水平的电生理证据丰富了我们对双向注意过程的理解:刺激驱动的自下而上的注意定向到显著但无关的刺激;以及自上而下将注意资源分配给刺激评估。
Although many studies have investigated the neural basis of top-down and bottom-up attention, it still requires refinement in both temporal and spatial terms. We used magnetoencephalography to investigate the spatiotemporal dynamics of high-gamma (52–100 Hz) activities during top-down and bottom-up visual attentional processes, aiming to extend the findings from functional magnetic resonance imaging and event-related potential studies. Fourteen participants performed a 3-stimulus visual oddball task, in which both infrequent non-target and target stimuli were presented. We identified high-gamma event-related synchronization in the left middle frontal gyrus, the left intraparietal sulcus, the left thalamus, and the visual areas in different time windows for the target and non-target conditions. We also found elevated imaginary coherence between the left intraparietal sulcus and the right middle frontal gyrus in the high-gamma band from 300 to 400 ms in the target condition, and between the left thalamus and the left middle frontal gyrus in theta band from 150 to 450 ms. In addition, the strength of high-gamma imaginary coherence between the left middle frontal gyrus and left intraparietal sulcus, between the left middle frontal gyrus and the right middle frontal gyrus, and the high-gamma power in the left thalamus predicted inter-subject variation in target detection response time. This source-level electrophysiological evidence enriches our understanding of bi-directional attention processes: stimulus-driven bottom-up attention orientation to a salient, but irrelevant stimulus; and top-down allocation of attentional resources to stimulus evaluation.
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