The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) study.
The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) study.
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DOI：
10.1186/1471-2431-14-184
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发表时间：
2014-07-18
期刊：
影响因子：
2.4
通讯作者：
Birch LL
中科院分区：
文献类型：
--
作者：
Paul IM;Williams JS;Anzman-Frasca S;Beiler JS;Makova KD;Marini ME;Hess LB;Rzucidlo SE;Verdiglione N;Mindell JA;Birch LL
由于早期生命发育具有长期的新陈代谢和行为后果，在发育可塑性期间进行干预可能会改变长期肥胖的风险。虽然已经确定了婴儿期的可改变因素，但直到最近，还没有对预防性干预措施进行测试。干预护士开始让婴儿沿着健康的轨迹成长(洞察力)。这项研究是一项纵向、随机、对照试验，旨在评估旨在一级预防肥胖的响应性父母干预措施。这种“育儿”干预被比作第一个出生的婴儿和他们的父母的家庭安全控制。Insight的核心假设是，响应性父母教育和特别是响应性喂养促进了自我调节和分担亲子喂养责任，降低了随后过度饮食和超重的风险。从一个产科病房登记了316名第一次怀孕的母亲和她们的足月新生儿。分娩两周后，双胞胎被随机分配到“育儿”或“安全”组。随后，研究护士对两组进行研究访问，包括在婴儿3-4、16、28和40周时进行家庭访问，然后在1、2和3岁时每年进行以诊所为基础的访问。这两组人都接受了围绕四种行为状态的干预成分：睡眠、烦躁、警觉和平静，以及溺水。主要的研究结果是3岁时的BMI z评分；其他结果包括与婴儿体重增加的模式、婴儿的睡眠卫生和持续时间、母亲的反应以及婴儿/幼儿焦虑和不安的缓解策略、母亲的喂养方式以及婴儿的饮食内容和体力活动有关的结果。正在收集与体重状况、饮食、心理健康和育儿能力感有关的产妇结局。将探索婴儿的气质作为父母教养效果的调节因素，并采集血液以获得体重状况的遗传预测因素。最后，洞察力参与者的第二个兄弟姐妹将参加一项仅限观察的研究，以探索兄弟姐妹之间的育儿差异，他们对体重结果的影响，以及洞察力干预对后续兄弟姐妹的影响。随着越来越多的证据表明早期生活经历对长期健康轨迹的重要性，Insight试验有能力在临床环境中为未来的肥胖预防工作提供信息。NCT01167270。已于2010年7月21日注册。
Because early life growth has long-lasting metabolic and behavioral consequences, intervention during this period of developmental plasticity may alter long-term obesity risk. While modifiable factors during infancy have been identified, until recently, preventive interventions had not been tested. The Intervention Nurses Starting Infants Growing on Healthy Trajectories (INSIGHT). Study is a longitudinal, randomized, controlled trial evaluating a responsive parenting intervention designed for the primary prevention of obesity. This “parenting” intervention is being compared with a home safety control among first-born infants and their parents. INSIGHT’s central hypothesis is that responsive parenting and specifically responsive feeding promotes self-regulation and shared parent–child responsibility for feeding, reducing subsequent risk for overeating and overweight. 316 first-time mothers and their full-term newborns were enrolled from one maternity ward. Two weeks following delivery, dyads were randomly assigned to the “parenting” or “safety” groups. Subsequently, research nurses conduct study visits for both groups consisting of home visits at infant age 3–4, 16, 28, and 40 weeks, followed by annual clinic-based visits at 1, 2, and 3 years. Both groups receive intervention components framed around four behavior states: Sleeping, Fussy, Alert and Calm, and Drowsy. The main study outcome is BMI z-score at age 3 years; additional outcomes include those related to patterns of infant weight gain, infant sleep hygiene and duration, maternal responsiveness and soothing strategies for infant/toddler distress and fussiness, maternal feeding style and infant dietary content and physical activity. Maternal outcomes related to weight status, diet, mental health, and parenting sense of competence are being collected. Infant temperament will be explored as a moderator of parenting effects, and blood is collected to obtain genetic predictors of weight status. Finally, second-born siblings of INSIGHT participants will be enrolled in an observation-only study to explore parenting differences between siblings, their effect on weight outcomes, and carryover effects of INSIGHT interventions to subsequent siblings. With increasing evidence suggesting the importance of early life experiences on long-term health trajectories, the INSIGHT trial has the ability to inform future obesity prevention efforts in clinical settings. NCT01167270. Registered 21 July 2010.
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影响因子：
8
作者：
Campbell, Karen J.;Lioret, Sandrine;Hesketh, Kylie D.
通讯作者：
Hesketh, Kylie D.
影响因子：
158.5
作者：
Barker, DJP;Osmond, C;Eriksson, JG
通讯作者：
Eriksson, JG
影响因子：
5.4
作者：
Berge, Jerica M.;MacLehose, Richard F.;Neumark-Sztainer, Dianne
通讯作者：
Neumark-Sztainer, Dianne
影响因子：
6.6
作者：
Cox, JL;Chapman, G;Jones, P
通讯作者：
Jones, P
DOI：
10.1111/infa.12002
发表时间：
2013
期刊：
Infancy : the official journal of the International Society on Infant Studies
影响因子：
--
作者：
Anzman-Frasca S;Liu S;Gates KM;Paul IM;Rovine MJ;Birch LL
通讯作者：
Birch LL