Neuronal Oscillations Indicate Sleep-dependent Changes in the Cortical Memory Trace
Neuronal Oscillations Indicate Sleep-dependent Changes in the Cortical Memory Trace
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神经元振荡表明皮质记忆轨迹中睡眠依赖性变化
DOI：
10.1162/jocn_a_01071
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发表时间：
2017
影响因子：
3.2
通讯作者：
T Gruber
中科院分区：
文献类型：
--
作者：
M Köster;H Finger;M Kater;C Schenk;T Gruber
睡眠促进新获得的联想记忆的巩固。在这里，我们使用人类脑电图中的神经元振荡来研究皮层记忆痕迹中的睡眠依赖性变化。检索活动的对象颜色协会进行了评估后立即编码和3小时的睡眠或清醒。睡眠对记忆表现有有益的影响，并导致在检索联想记忆时与事件相关的θ和γ功率降低。此外，事件相关的α抑制衰减在唤醒组记忆和新的刺激。没有睡眠依赖性的变化，检索活动的遗漏项目或项目检索没有颜色。因此，睡眠依赖的θ和γ振荡的减少是特定于联想记忆的检索。与睡眠依赖性记忆巩固的理论解释一致，θ波降低可能表明中颞叶活动减少，因为睡眠期间信息转移到新皮层网络，而顶叶γ波降低可能反映了突触缩小的影响。清醒组中阿尔法抑制的变化可能表明注意力资源减少，这也可能导致该组记忆表现较低。这些发现表明，睡眠期间联想记忆的巩固与皮层记忆痕迹的深刻变化有关，并依赖于多个神经元过程的协同工作。
Sleep promotes the consolidation of newly acquired associative memories. Here we used neuronal oscillations in the human EEG to investigate sleep-dependent changes in the cortical memory trace. The retrieval activity for object–color associations was assessed immediately after encoding and after 3 hr of sleep or wakefulness. Sleep had beneficial effects on memory performance and led to reduced event-related theta and gamma power during the retrieval of associative memories. Furthermore, event-related alpha suppression was attenuated in the wake group for memorized and novel stimuli. There were no sleep-dependent changes in retrieval activity for missed items or items retrieved without color. Thus, the sleep-dependent reduction in theta and gamma oscillations was specific for the retrieval of associative memories. In line with theoretical accounts on sleep-dependent memory consolidation, decreased theta may indicate reduced mediotemporal activity because of a transfer of information into neocortical networks during sleep, whereas reduced parietal gamma may reflect effects of synaptic downscaling. Changes in alpha suppression in the wake group possibly index reduced attentional resources that may also contribute to a lower memory performance in this group. These findings indicate that the consolidation of associative memories during sleep is associated with profound changes in the cortical memory trace and relies on multiple neuronal processes working in concert.
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DOI：
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发表时间：
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期刊：
影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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