Delayed onset of a daytime nap facilitates retention of declarative memory.
Delayed onset of a daytime nap facilitates retention of declarative memory.
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DOI：
10.1371/journal.pone.0012131
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发表时间：
2010-08-12
期刊：
影响因子：
3.7
通讯作者：
Fishbein W
中科院分区：
文献类型：
--
作者：
Alger SE;Lau H;Fishbein W
学习后再睡一段时间，即使只是小睡一下，也能促进记忆的巩固。现在普遍认识到，睡眠有助于稳定睡眠前获得的信息。然而，睡眠对陈述性记忆保持的影响的时间性质还有待了解。我们研究了延迟的午睡发作对识别中性图片刺激的影响，增加了空间成分。参与者完成了一个初步的研究会议，涉及150人，地点和物体的中性图片。紧接着图片介绍，参与者被要求作出识别判断的一个子集的“旧”，以前看到的，图片与混杂的“新”图片。然后，参与者被分为四组，他们要么在学习后立即小睡90分钟，要么在学习后2小时或4小时小睡，要么在实验期间保持清醒。在最初学习6小时后，参与者再次测试剩余的“旧”图片，并混合“新”图片。有趣的是，我们发现睡眠对记忆痕迹的稳定作用反映在午睡前的平均时间与测试到重新测试的表现下降之间存在显著的负相关性（p = 0.001）。 我们发现两组之间的相互作用和他们的表现从测试到重新测试（p = 0.010），4小时延迟组的表现明显优于立即睡觉的人和保持清醒的人（分别为p= 0.044，p = 0.010）。 睡眠数据的分析显示，慢波睡眠（SWS）的数量和睡眠开始前的延迟时间之间存在显著的正相关性（p = 0.048）。 这些发现增加了对人类记忆处理的理解，表明随着时间的推移，清醒处理和睡眠需求的稳态增加等因素调节了睡眠对巩固中性陈述性记忆的重要性。
Learning followed by a period of sleep, even as little as a nap, promotes memory consolidation. It is now generally recognized that sleep facilitates the stabilization of information acquired prior to sleep. However, the temporal nature of the effect of sleep on retention of declarative memory is yet to be understood. We examined the impact of a delayed nap onset on the recognition of neutral pictorial stimuli with an added spatial component. Participants completed an initial study session involving 150 neutral pictures of people, places, and objects. Immediately following the picture presentation, participants were asked to make recognition judgments on a subset of “old”, previously seen, pictures versus intermixed “new” pictures. Participants were then divided into one of four groups who either took a 90-minute nap immediately, 2 hours, or 4 hours after learning, or remained awake for the duration of the experiment. 6 hours after initial learning, participants were again tested on the remaining “old” pictures, with “new” pictures intermixed. Interestingly, we found a stabilizing benefit of sleep on the memory trace reflected as a significant negative correlation between the average time elapsed before napping and decline in performance from test to retest (p = .001). We found a significant interaction between the groups and their performance from test to retest (p = .010), with the 4-hour delay group performing significantly better than both those who slept immediately and those who remained awake (p = .044, p = .010, respectively). Analysis of sleep data revealed a significant positive correlation between amount of slow wave sleep (SWS) achieved and length of the delay before sleep onset (p = .048). The findings add to the understanding of memory processing in humans, suggesting that factors such as waking processing and homeostatic increases in need for sleep over time modulate the importance of sleep to consolidation of neutral declarative memories.
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影响因子：
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通讯作者：
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DOI：
10.1073/pnas.0705454104
发表时间：
2007-11-20
影响因子：
11.1
作者：
Gais, Steffen;Albouy, Genevieve;Peigneux, Philippe
通讯作者：
Peigneux, Philippe