Increased expression of extracellular matrix metalloproteinase inducer (CD147) in multiple myeloma: role in regulation of myeloma cell proliferation.
Increased expression of extracellular matrix metalloproteinase inducer (CD147) in multiple myeloma: role in regulation of myeloma cell proliferation.
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作者：
多发性骨髓瘤（MM）之前是无症状的癌前状态，意义不明的单克隆丙种球蛋白病（MGUS）。虽然MGUS患者可能保持稳定多年，他们是在增加的风险进展为MM。更好地了解相关的分子变化的基础上从无症状的疾病状态的转变是迫切需要的。我们的研究表明，第一次，CD147分子（细胞外基质金属蛋白酶诱导剂）可能发挥重要的生物学作用，在MM。我们首先证明，CD147过表达MM浆细胞（PC）与正常和癌前PC。接下来，功能研究显示天然CD 147配体亲环素B刺激MM细胞生长。此外，当MM患者的PC显示双峰CD 147表达被分为CD 147明亮和CD 147暗淡的人口和分析的增殖潜力，我们发现，CD 147明亮的PC显示出显着更高的细胞增殖水平比CD 147暗淡的PC。最后，CD147沉默显著减弱MM细胞增殖。总之，这些数据表明，CD147分子在MM细胞增殖中起着关键作用，并可能作为减少这种疾病的增殖区室的有吸引力的目标。
Multiple myeloma (MM) is preceded by the asymptomatic premalignant state, monoclonal gammopathy of undetermined significance (MGUS). Although MGUS patients may remain stable for years, they are at increased risk of progressing to MM. A better understanding of the relevant molecular changes underlying the transition from an asymptomatic to symptomatic disease state is urgently needed. Our studies show for the first time that the CD147 molecule (extracellular matrix metalloproteinase inducer) may be playing an important biological role in MM. We first demonstrate that CD147 is over-expressed in MM plasma cells (PCs) vs. normal and premalignant PCs. Next, functional studies revealed that the natural CD147 ligand, cyclophilin B, stimulates MM cell growth. Moreover, when MM patient PCs displaying bimodal CD147 expression were separated into CD147bright and CD147dim populations and analyzed for proliferation potential, we discovered that CD147bright PCs displayed significantly higher levels of cell proliferation than did CD147dim PCs. Lastly, CD147 silencing significantly attenuated MM cell proliferation. Taken together, these data suggest that the CD147 molecule plays a key role in MM cell proliferation and may serve as an attractive target for reducing the proliferative compartment of this disease.
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影响因子：
45.3
作者：
Mateo, Gema;Montalban, M. Angeles;Miguel, Jesus F. San
通讯作者：
Miguel, Jesus F. San
影响因子：
6.4
作者：
Li, Yu;Xu, Jing;Chen, Zhi-Nan
通讯作者：
Chen, Zhi-Nan
DOI：
10.1073/pnas.052284899
发表时间：
2002-03-05
影响因子：
11.1
作者：
Allain, F;Vanpouille, C;Spik, G
通讯作者：
Spik, G
影响因子：
6.4
作者：
MURAOKA, K;NABESHIMA, K;KOONO, M
通讯作者：
KOONO, M
影响因子：
8.9
作者：
KYLE, RA
通讯作者：
KYLE, RA