Very late vasomotor responses and gene expression with bioresorbable scaffolds and metallic drug-eluting stents.
Very late vasomotor responses and gene expression with bioresorbable scaffolds and metallic drug-eluting stents.
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DOI：
10.1002/ccd.29819
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Samady H
中科院分区：
文献类型：
--
作者：
Koh JS;Gogas BD;Kumar S;Benham JJ;Sur S;Spilias N;Kumar A;Giddens DP;Rapoza R;Kereiakes DJ;Stone G;Jo H;Samady H
目的是研究植入可吸收生物血管支架（BVS）和金属药物洗脱支架（DES）的动脉的长期血管舒缩反应及炎症变化。
临床证据表明，与DES相比，BVS的靶病变失败率更高。然而，尚不清楚BVS较高的事件发生率是否与内皮功能障碍或与聚合物降解相关的炎症有关。
将10个Absorb BVS和6个Xience V DES随机植入6只非动脉粥样硬化猪的主要冠状动脉中。在4年时，通过定量冠状动脉造影对冠状动脉内注入乙酰胆碱（Ach）的反应在体内评估血管舒缩反应，并通过对前列腺素F2-α（PGF2-α）、P物质和缓激肽的生物力学反应以及基因表达分析在体外进行评估。
与Xience V支架内相比，植入Absorb BVS的动脉在注入Ach后血管收缩反应显著恢复。与Xience V治疗节段相比，PGF2-α诱导的Absorb BVS治疗节段的收缩性显著更强，且与Xience V相比，Absorb BVS的内皮依赖性血管舒张作用更强。基因表达分析表明，与Absorb BVS治疗的动脉节段相比，金属支架治疗的动脉中促炎的淋巴毒素-β受体（LTβR）信号通路显著上调。
在4年时，与Xience V相比，Absorb BVS治疗的动脉显示出血管舒缩反应的显著更大程度恢复。基因分析表明，与Xience V治疗的血管相比，Absorb BVS治疗的动脉在4年时出现机械生物学修复。
To investigate the long-term vasomotor response and inflammatory changes in Absorb bioresorbable vascular scaffold (BVS) and metallic drug-eluting stent (DES) implanted artery. Clinical evidence has demonstrated that compared to DES, BVS is associated with higher rates of target lesion failure. However, it is not known whether the higher event rates observed with BVS are related to endothelial dysfunction or inflammation associated with polymer degradation. Ten Absorb BVS and six Xience V DES were randomly implanted in the main coronaries of six nonatherosclerotic swine. At 4-years, vasomotor response was evaluated in vivo by quantitative coronary angiography response to intracoronary infusion of Ach and ex vivo by the biomechanical response to prostaglandin F2-α (PGF2-α), substance P and bradykinin and gene expression analysis. Absorb BVS implanted arteries showed significantly restored vasoconstrictive responses after Ach compared to in-stent Xience V. The contractility of Absorb BVS treated segments induced by PGF2-α was significantly greater compared to Xience V treated segments and endothelial-dependent vasorelaxation was greater with Absorb BVS compared to Xience V. Gene expression analyses indicated the pro-inflammatory lymphotoxin-beta receptor (LTβR) signaling pathway was significantly upregulated in arteries treated with a metallic stent compared to Absorb BVS treated arterial segments. At 4 years, arteries treated with Absorb BVS compared with Xience V, demonstrate significantly greater restoration of vasomotor responses. Genetic analysis suggests mechanobiologic reparation of Absorb BVS treated arteries at 4 years as opposed to Xience V treated vessels.
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影响因子：
24
作者：
Stone, Gregg W.;Abizaid, Alexandre;Serruys, Patrick W.
通讯作者：
Serruys, Patrick W.
影响因子：
64.5
作者：
BROWNING, JL;NGAMEK, A;WARE, CF
通讯作者：
WARE, CF
影响因子：
--
作者：
Jufri NF;Mohamedali A;Avolio A;Baker MS
通讯作者：
Baker MS
DOI：
10.1136/hrt.2009.166017
发表时间：
2009-09
期刊：
Heart (British Cardiac Society)
影响因子：
--
作者：
Lavi S;Bae JH;Rihal CS;Prasad A;Barsness GW;Lennon RJ;Holmes DR Jr;Lerman A
通讯作者：
Lerman A
影响因子：
24
作者：
Nakazawa, Gaku;Otsuka, Fumiyuki;Nakano, Masataka;Vorpahl, Marc;Yazdani, Saami K.;Ladich, Elena;Kolodgie, Frank D.;Finn, Aloke V.;Virmani, Renu
通讯作者：
Virmani, Renu