Different mechanisms are responsible for dishabituation of electrophysiological auditory responses to a change in acoustic identity than to a change in stimulus location.
Different mechanisms are responsible for dishabituation of electrophysiological auditory responses to a change in acoustic identity than to a change in stimulus location.
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DOI：
10.1016/j.nlm.2013.08.010
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发表时间：
2013-11
影响因子：
2.7
通讯作者：
Jarvis, Erich D.
中科院分区：
文献类型：
--
作者：
Smulders, Tom V.;Jarvis, Erich D.
重复暴露于听觉刺激导致听觉系统中的电生理和立即早期基因（IEG）表达反应的习惯化。一种新的听觉刺激以一种使人丧失适应的形式恢复了这种反应。这被解释为这种新刺激的新记忆形成的开始。在其他相同的听觉刺激的位置的变化也可以disabituate IEG的表达反应。这被解释为将刺激身份和刺激位置整合到单个听觉对象中，编码在听觉系统的放电模式中。在这项研究中，我们进一步验证了这一假设。使用慢性多电极阵列记录多个单位的活动，从听觉系统的清醒和行为斑胸草雀，我们发现，习惯化发生重复暴露于同一首歌和disabituation与一个新的歌曲，类似于描述的头部固定，克制的动物。当同样的听觉刺激被移到一个新的位置时，大部分的记录位点也表现出disabituation。然而，当歌曲在8个交错位置之间随机移动时，习惯化独立于位置的连续变化而发生。相比之下，当8个不同的听觉刺激交错都来自同一个位置，一个单独的习惯发生每个刺激。这一结果表明，神经元的记忆的声学身份和空间位置是不同的，和allocentric位置的刺激不编码的一部分，记忆的听觉对象，而其声学特性。我们推测，相反，从一个稳定的位置的声音的变化发生的disabituation是由于位置变化的意外，可能是由于不同的潜在机制比disabituation和不同的听觉刺激单独的习惯。
Repeated exposure to an auditory stimulus leads to habituation of the electrophysiological and immediate-early-gene (IEG) expression response in the auditory system. A novel auditory stimulus reinstates this response in a form of dishabituation. This has been interpreted as the start of new memory formation for this novel stimulus. Changes in the location of an otherwise identical auditory stimulus can also dishabituate the IEG expression response. This has been interpreted as an integration of stimulus identity and stimulus location into a single auditory object, encoded in the firing patterns of the auditory system. In this study, we further tested this hypothesis. Using chronic multi-electrode arrays to record multi-unit activity from the auditory system of awake and behaving zebra finches, we found that habituation occurs to repeated exposure to the same song and dishabituation with a novel song, similar to that described in head-fixed, restrained animals. A large proportion of recording sites also showed dishabituation when the same auditory stimulus was moved to a novel location. However, when the song was randomly moved among 8 interleaved locations, habituation occurred independently of the continuous changes in location. In contrast, when 8 different auditory stimuli were interleaved all from the same location, a separate habituation occurred to each stimulus. This result suggests that neuronal memories of the acoustic identity and spatial location are different, and that allocentric location of a stimulus is not encoded as part of the memory for an auditory object, while its acoustic properties are. We speculate that, instead, the dishabituation that occurs with a change from a stable location of a sound is due to the unexpectedness of the location change, and might be due to different underlying mechanisms than the dishabituation and separate habituations to different acoustic stimuli.
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影响因子：
9.8
作者：
Maddox RK;Billimoria CP;Perrone BP;Shinn-Cunningham BG;Sen K
通讯作者：
Sen K
影响因子：
3.7
作者：
Feenders, Gesa;Liedvogel, Miriam;Rivas, Miriam;Zapka, Manuela;Horita, Haruhito;Hara, Erina;Wada, Kazuhiro;Mouritsen, Henrik;Jarvis, Erich D.
通讯作者：
Jarvis, Erich D.
影响因子：
2.4
作者：
Iriarte, J;Urrestarazu, E;Artieda, J
通讯作者：
Artieda, J
DOI：
10.1073/pnas.93.5.1950
发表时间：
1996-03-05
影响因子：
11.1
作者：
Chew, SJ;Vicario, DS;Nottebohm, F
通讯作者：
Nottebohm, F
影响因子：
3.7
作者：
Joyce, CA;Gorodnitsky, IF;Kutas, M
通讯作者：
Kutas, M