Polybrominated Diphenyl Ether Serum Concentrations and Depressive Symptomatology in Pregnant African American Women.
Polybrominated Diphenyl Ether Serum Concentrations and Depressive Symptomatology in Pregnant African American Women.
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DOI：
10.3390/ijerph18073614
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发表时间：
2021-03-31
影响因子：
--
通讯作者：
McCauley LA
中科院分区：
文献类型：
--
作者：
Mutic AD;Barr DB;Hertzberg VS;Brennan PA;Dunlop AL;McCauley LA
(1)直到2004年，多溴联苯醚（PBDEs）在美国广泛生产，但在环境中具有高度持久性。多溴二苯醚破坏正常神经内分泌通路导致抑郁和其他神经系统症状的可能性在很大程度上尚未得到充分研究。本研究调查了孕妇接触多溴二苯醚是否与产前抑郁症状有关。(2)收集了193名妊娠8-14周的非裔美国孕妇的数据。分析血清多溴二苯醚和抑郁症状，并计算混合效应。(3)与全国平均水平相比，美国东南部城市非裔美国孕妇患抑郁症的风险较高（27%）。发现多溴二苯醚含量增加。妊娠队列中BDE-47和-99暴露与抑郁症状显著相关。使用爱丁堡抑郁量表临界值≥10，PBDE混合物的加权体重负担估计值与轻度至中度抑郁的高风险相关（OR = 2.93; CI 1.18, 7.82）。(4)由于产前抑郁可能在产后加重，减少多溴二苯醚暴露可能具有重要的临床意义。
(1) Polybrominated diphenyl ethers (PBDEs) were widely produced in the United States until 2004 but remain highly persistent in the environment. The potential for PBDEs to disrupt normal neuroendocrine pathways resulting in depression and other neurological symptoms is largely understudied. This study examined whether PBDE exposure in pregnant women was associated with antenatal depressive symptomatology. (2) Data were collected from 193 African American pregnant women at 8–14 weeks gestation. Serum PBDEs and depressive symptoms were analyzed and a mixture effect was calculated. (3) Urban pregnant African American women in the Southeastern United States had a high risk of depression (27%) compared to the National average. Increased levels of PBDEs were found. BDE-47 and -99 exposures are significantly associated with depressive symptomatology in the pregnant cohort. The weighted body burden estimate of the PBDE mixture was associated with a higher risk of mild to moderate depression using an Edinburgh Depression Scale cutoff score of ≥10 (OR = 2.93; CI 1.18, 7.82). (4) Since antenatal depression may worsen in postpartum, reducing PBDE exposure may have significant clinical implications.
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作者：
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通讯作者：
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