Olfactory receptors: G protein-coupled receptors and beyond.
Olfactory receptors: G protein-coupled receptors and beyond.
复制标题
DOI：
10.1111/j.1471-4159.2009.06085.x
复制
发表时间：
2009-06
影响因子：
4.7
通讯作者：
Munger SD
中科院分区：
文献类型：
--
作者：
Spehr M;Munger SD
感知化学环境对所有生物都至关重要。从昆虫到哺乳动物的各种动物利用高度组织化的嗅觉系统来检测、编码和处理可能携带对健康、生存、社会互动和繁殖至关重要的重要信息的化学刺激。因此，对于动物来说，正确地解释和反应它们的环境，嗅觉系统必须以适当的选择性和敏感性识别化学刺激。由于嗅觉受体蛋白在特异性识别各种刺激物中起着重要作用，因此了解它们如何与其同源配体相互作用并使其稳定是一个高度优先事项。哺乳动物气味受体（odorant receptor，OR）基因家族是最大的G蛋白偶联受体（G protein-coupled receptor，GPCR）基因家族，近20年来，GPCR在脊椎动物和无脊椎动物嗅觉中的作用受到了广泛关注。然而，已经清楚的是，嗅觉受体的"家族"是高度多样化的，酶和配体门控离子通道以及GPCR在嗅觉刺激的主要检测中具有作用。
Sensing the chemical environment is critical for all organisms. Diverse animals from insects to mammals utilize highly organized olfactory system to detect, encode, and process chemostimuli that may carry important information critical for health, survival, social interactions and reproduction. Therefore, for animals to properly interpret and react to their environment it is imperative that the olfactory system recognizes chemical stimuli with appropriate selectivity and sensitivity. Because olfactory receptor proteins play such an essential role in the specific recognition of diverse stimuli, understanding how they interact with and transduce their cognate ligands is a high priority. In the nearly two decades since the discovery that the mammalian odorant receptor (OR) gene family constitutes the largest group of G protein-coupled receptor (GPCR) genes, much attention has been focused on the roles of GPCRs in vertebrate and invertebrate olfaction. However, is has become clear that the “family” of olfactory receptors is highly diverse, with roles for enzymes and ligand-gated ion channels as well as GPCRs in the primary detection of olfactory stimuli.
登录
查看更多内容
影响因子：
9.8
作者：
Benton, Richard;Sachse, Silke;Michnick, Stephen W;Vosshall, Leslie B
通讯作者：
Vosshall, Leslie B
影响因子：
10.7
作者：
De la Cruz, Omar;Blekhman, Ran;Gilad, Yoav
通讯作者：
Gilad, Yoav
DOI：
10.1016/j.bbrc.2007.12.153
发表时间：
2008-03-07
影响因子：
3.1
作者：
Duda, Teresa;Sharma, Rameshwar K.
通讯作者：
Sharma, Rameshwar K.
影响因子：
2.6
作者：
Bohbot, J.;Pitts, R. J.;Zwiebel, L. J.
通讯作者：
Zwiebel, L. J.
影响因子：
64.8
作者：
Chamero, Pablo;Marton, Tobias F.;Stowers, Lisa
通讯作者：
Stowers, Lisa