Protein import into chloroplasts--how chaperones feature into the game.

Protein import into chloroplasts--how chaperones feature into the game.
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蛋白质导入叶绿体——伴侣如何在游戏中发挥作用。

DOI:
10.1016/j.bbamem.2010.07.021
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发表时间:
2011
期刊:
Biochimica et biophysica acta
影响因子:
--
通讯作者:
B. Bölter
B. Bölter
中科院分区:
--
文献类型:
--
作者:
S. Schwenkert;J. Soll;B. Bölter

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叶绿体起源于一个内共生事件,在这个事件中,一个古老的光合蓝藻被一个线粒体真核宿主细胞吞没。在进化过程中,内共生体由于遗传信息从原核生物基因组向宿主细胞核的大量转移而丧失了其自主性。因此,蛋白质输入机制的发展对于蛋白质的重新定位是必要的,这些蛋白质现在是核编码的,并在细胞质中合成,但最终要进入叶绿体。细胞器的发生和维持需要宿主细胞和细胞器之间的转录、翻译和蛋白质输入的紧密协调。本文综述了外、内包膜中的易位复合物,重点介绍了分子伴侣的作用。这篇文章是题为蛋白质跨膜易位或插入膜的特刊的一部分。
Chloroplasts originated from an endosymbiotic event, in which an ancestral photosynthetic cyanobacterium was engulfed by a mitochondriate eukaryotic host cell. During evolution, the endosymbiont lost its autonomy by means of a massive transfer of genetic information from the prokaryotic genome to the host nucleus. Consequently, the development of protein import machineries became necessary for the relocation of proteins that are now nuclear-encoded and synthesized in the cytosol but destined for the chloroplast. Organelle biogenesis and maintenance requires a tight coordination of transcription, translation and protein import between the host cell and the organelle. This review focuses on the translocation complexes in the outer and inner envelope membrane with a special emphasis on the role of molecular chaperones. This article is part of a Special Issue entitled Protein translocation across or insertion into membranes.
DOI: 10.1073/pnas.0607150103
发表时间: 2006-10-24
影响因子: 11.1
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