Astaxanthin attenuates pulmonary fibrosis through lncITPF and mitochondria-mediated signal pathways.
Astaxanthin attenuates pulmonary fibrosis through lncITPF and mitochondria-mediated signal pathways.
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虾青素通过 lncITPF 和线粒体介导的信号通路减轻肺纤维化
DOI：
10.1111/jcmm.15477
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发表时间：
2020-09
影响因子：
5.3
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Chen H;Wang J;Li R;Lv C;Xu P;Wang Y;Song X;Zhang J
肺纤维化是一种以肺上皮损伤、成纤维细胞活化、细胞外基质沉积和组织结构破坏为特征的慢性间质性肺疾病。然而，仍然没有有效的药物治疗。因此，研究肺纤维化的机制并寻找有效的药物已成为呼吸系统疾病领域的重要问题。肺纤维化的典型特征是成纤维细胞增殖和迁移激活。因此，活化的成纤维细胞增殖和迁移的异常是治疗肺纤维化的主要问题。长链非编码RNA（lncRNA）是ncRNA的一个神秘亚类，调节各种基本生物过程并参与疾病的发生和发展。然而，以lncRNA作为药物作用治疗靶点的研究却鲜有报道。我们的团队首先鉴定了差异表达的lncRNA，并揭示lncITPF是肺纤维化中高度上调的lncRNA。特别是，在特发性肺纤维化患者的血液中检测到lncITPF。临床分析表明lncITPF与纤维化程度呈正相关。受试者工作特征（ROC）曲线表明特异性和敏感性值分别为 95.0 和 64.3。 ROC曲线下面积为0.804，表明lncITPF可以作为IPF的诊断生物标志物。然而，lncITPF 作为抗肺纤维化药物作用的治疗靶点是否有效仍不清楚。本研究对lncITPF作为虾青素的治疗靶点进行了深入探讨。研究结果表明，虾青素通过 lncITPF 和线粒体介导的信号通路阻断激活的成纤维细胞增殖和迁移，从而减轻肺纤维化。
Pulmonary fibrosis is a chronic interstitial lung disease characterized by pulmonary epithelial injury, fibroblast activation, extracellular matrix deposition, and tissue structure destruction. However, an effective drug treatment remains unavailable. Therefore, studying the mechanism of pulmonary fibrogenesis and finding effective drugs have become important problems in the field of respiratory diseases. Pulmonary fibrosis is typically characterized by activated fibroblast proliferation and migration. Hence, abnormality in activated fibroblast proliferation and migration is a major concern for treating pulmonary fibrosis. Long noncoding RNA (lncRNA) is an enigmatic subclass of ncRNA that regulates various fundamental biological processes and participates in disease occurrence and development. However, studies on lncRNA as the therapeutic target of drug action are rarely reported. Our group first identified differentially expressed lncRNAs and revealed that lncITPF is a highly upregulated lncRNA in lung fibrosis. In particular, lncITPF is detected in the blood of patients with idiopathic pulmonary fibrosis. Clinical analysis shows that lncITPF is positively correlated with the degree of fibrosis. The receiver operating characteristic (ROC) curve indicates that the specificity and sensitivity values are 95.0 and 64.3, respectively. The area under the ROC curve is 0.804, indicating that lncITPF can be a diagnostic biomarker for IPF. However, whether lncITPF is effective as a therapeutic target of drug action against pulmonary fibrosis remains unclear. In this study, lncITPF acting as the therapeutic target of astaxanthin was explored in depth. The findings elucidated that astaxanthin blocks the activated fibroblast proliferation and migration through lncITPF and mitochondria‐mediated signal pathways to alleviate pulmonary fibrogenesis.
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影响因子：
3.3
作者：
Polyakov, Nikolay E.;Magyar, Adam;Kispert, Lowell D.
通讯作者：
Kispert, Lowell D.
DOI：
10.1056/nejmoa072366
发表时间：
2007-08-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Samani NJ;Erdmann J;Hall AS;Hengstenberg C;Mangino M;Mayer B;Dixon RJ;Meitinger T;Braund P;Wichmann HE;Barrett JH;König IR;Stevens SE;Szymczak S;Tregouet DA;Iles MM;Pahlke F;Pollard H;Lieb W;Cambien F;Fischer M;Ouwehand W;Blankenberg S;Balmforth AJ;Baessler A;Ball SG;Strom TM;Braenne I;Gieger C;Deloukas P;Tobin MD;Ziegler A;Thompson JR;Schunkert H;WTCCC and the Cardiogenics Consortium
通讯作者：
WTCCC and the Cardiogenics Consortium
影响因子：
4.6
作者：
Kim, Hye-Youn;Kim, Young-Mi;Hong, Suntaek
通讯作者：
Hong, Suntaek
影响因子：
64.5
作者：
Atianand MK;Hu W;Satpathy AT;Shen Y;Ricci EP;Alvarez-Dominguez JR;Bhatta A;Schattgen SA;McGowan JD;Blin J;Braun JE;Gandhi P;Moore MJ;Chang HY;Lodish HF;Caffrey DR;Fitzgerald KA
通讯作者：
Fitzgerald KA
影响因子：
5.4
作者：
Donà G;Kožuh I;Brunati AM;Andrisani A;Ambrosini G;Bonanni G;Ragazzi E;Armanini D;Clari G;Bordin L
通讯作者：
Bordin L