Surface-Modified Graphene Oxide with Compatible Interface Enhances Poly-L-Lactic Acid Bone Scaffold
Surface-Modified Graphene Oxide with Compatible Interface Enhances Poly-L-Lactic Acid Bone Scaffold
复制标题
具有兼容界面的表面改性氧化石墨烯增强聚左旋乳酸骨支架
DOI：
10.1155/2020/5634096
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发表时间：
2020-03
影响因子：
--
通讯作者：
Shuai Cijun
中科院分区：
文献类型：
--
作者：
Wang Guoyong;He Chongxian;Yang Wengjing;Qi Fangwei;Qian Guowen;Peng Shuping;Shuai Cijun
氧化石墨烯（GO）具有优异的机械强度和高比表面积，通常用作聚合物的增强相。本研究将氧化石墨烯与l -乳酸单体（表示为GO@PLLA）接枝，克服基体中的聚集，然后将其掺入选择性激光烧结制备的聚l -乳酸（PLLA）支架中。在杂化支架中，GO@PLLA在基质中分散均匀。此外，GO@PLLA与PLLA基体之间形成机械互锁，增强了界面结合。另一方面，非均相分布的氧化石墨烯作为有效的成核剂，促进了结晶。结果表明，支架的抗拉和抗压强度分别提高了143.3%和127.6%。同时，支架的降解率提高了37.9%，这可能归因于氧化石墨烯上丰富的亲水性官能团。此外，支架具有良好的生物活性和生物相容性。由此可见，该复合支架具有潜在的骨组织工程应用潜力。
Graphene oxide (GO) usually serves as a reinforce phase in polymer because of its superior mechanical strength and high specific surface area. In this work, GO was grafted with L-lactic acid monomer (denoted as GO@PLLA) to overcome the aggregation in matrix and then incorporated into the poly-L-lactic acid (PLLA) scaffold fabricated by selective laser sintering. In hybrid scaffold, GO@PLLA exhibited uniform dispersion in the matrix. Furthermore, mechanical interlock between GO@PLLA and PLLA matrix formed and reinforced the interface bonding. On the other hand, the heterogeneous distributed GO acted as effective nucleating agent and resultantly enhanced the crystallization. Results showed that the tensile and compressive strength of scaffolds increased by 143.3% and 127.6%, respectively. Meanwhile, the scaffold exhibited an increased degradation rate of 37.9%, which could be attributed to the abundant hydrophilic functional groups on GO. Moreover, the scaffold exhibited favorable bioactivity and biocompatibility. Herein, the developed hybrid scaffold showed potential capacity for bone tissue engineering.
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