Vitamin D receptor rs2228570 polymorphism and invasive ovarian carcinoma risk: pooled analysis in five studies within the Ovarian Cancer Association Consortium.
Vitamin D receptor rs2228570 polymorphism and invasive ovarian carcinoma risk: pooled analysis in five studies within the Ovarian Cancer Association Consortium.
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DOI：
10.1002/ijc.25403
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发表时间：
2011-02-15
影响因子：
6.4
通讯作者：
Goodman, Marc T.
中科院分区：
文献类型：
--
作者：
Lurie, Galina;Wilkens, Lynne R.;Thompson, Pamela J.;Carney, Michael E.;Palmieri, Rachel T.;Pharoah, Paul D. P.;Song, Honglin;Hogdalls, Estrid;Kjaer, Susanne Kruger;DiCioccio, Richard A.;McGuire, Valerie;Whittemore, Alice S.;Gayther, Simon A.;Gentry-Maharaj, Aleksandra;Menon, Usha;Ramus, Susan J.;Goodman, Marc T.
关键词：
对1820名非西班牙裔白人患者和3479名对照进行了卵巢癌协会内5项基于人群的病例对照研究，研究了侵袭性卵巢癌风险与维生素D受体(VDR)基因功能多态rs2228570(又名rs10735810；FokI多态)的关系。用非条件Logistic回归估计优势比(OR)和95%可信区间(CI)。在所有研究中，携带罕见T等位基因的女性患卵巢癌的风险比携带CC基因的女性高；每个T等位基因的拷贝与风险增加9%相关(OR=1.09；95%CI：1.01-1.19；p=0.04)。研究之间没有观察到显著的异质性(p=0.37)，在从夏威夷研究中排除数据集后，重复研究中rs2228570的风险关联没有变化(OR=1.09；95%CI：1.00-1.19；p=0.06)。在年轻女性(50岁与50岁或50岁以上)中观察到rs2228570与风险有更强的关联(p=0.04)。在所有研究中，年轻女性每拷贝T等位基因的风险增加24%(OR=1.24；95%CI：1.04-1.47；p=0.02)。排除夏威夷数据后，这种相关性在统计学上仍然显著(OR=1.20；95%CI：1.01-1.43；p=0.04)。没有观察到分期(p=0.46)、肿瘤组织学(p=0.98)或诊断到问诊之间的时间(p=0.94)的相关性的异质性。这一合并分析进一步证明VDR rs2228570多态可能影响卵巢癌的易感性。
The association of invasive ovarian carcinoma risk with the functional polymorphism rs2228570 (aka rs10735810; FokI polymorphism) in the vitamin D receptor (VDR) gene was examined in 1820 white non-Hispanic cases and 3479 controls in a pooled analysis of five population-based case-control studies within the Ovarian Cancer Association Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. Carriers of the rare T allele were at increased risk of ovarian carcinoma compared to women with the CC genotype in all studies combined; each copy of the T allele was associated with a modest 9% increased risk (OR=1.09; 95% CI:1.01–1.19; p=0.04). No significant heterogeneity among studies was observed (p=0.37) and, after excluding the dataset from the Hawaii study, the risk association for rs2228570 among replication studies was unchanged (OR=1.09; 95% CI: 1.00–1.19; p=0.06). A stronger association of rs2228570 with risk was observed among younger women (aged < 50 years versus 50 years or older) (p=0.04). In all studies combined, the increased risk per copy of the T allele among younger women was 24% (OR=1.24; 95% CI: 1.04–1.47; p=0.02). This association remained statistically significant after excluding the Hawaii data (OR= 1.20; 95% CI: 1.01–1.43; p=0.04). No heterogeneity of the association was observed by stage (p= 0.46), tumor histology (p=0.98), or time between diagnosis and interview (p=0.94). This pooled analysis provides further evidence that the VDR rs2228570 polymorphism might influence ovarian cancer susceptibility.
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