Relationship Between Single Nucleotide Polymorphisms and the Toxicy and Side Effects of Paclitaxel and Platinum-Based Chemotherapy in Patients with Malignant Tumors
Relationship Between Single Nucleotide Polymorphisms and the Toxicy and Side Effects of Paclitaxel and Platinum-Based Chemotherapy in Patients with Malignant Tumors
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单核苷酸多态性与恶性肿瘤患者紫杉醇及铂类化疗毒副作用的关系
DOI：
10.31487/j.cor.2019.05.06
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发表时间：
2019-10
期刊：
影响因子：
--
通讯作者：
WU Yi-Ting
中科院分区：
文献类型：
--
作者：
LIU Yan-Wen;ZHU Yi-Qian;CHEN Bao-An;GUO Nan-Nan;WU Yi-Ting
目的：探讨单核苷酸多态性（SNPs）与紫杉醇联合铂类化疗毒副作用的关系，为恶性肿瘤患者的个体化治疗提供建议。方法：对17例恶性肿瘤患者进行DNA位点测定并分析。研究结果：1.所有17例入选标本的氟尿嘧啶相关基因均为18DPYD*2A（476002G>A）GG型、153DPYD*13（1679T>G）TT型、154DPYD（2846A>T）TT型，且DPYD合成酶活性均为阴性。21GSTP1（313A>G）多态性位点突变率为25.0%（4例），29XRCC1（16323944T>C）多态性位点突变率为90.9%（10例），62ABCB1（3435C>T）多态性位点突变率为52.9%（9例），68MTHFR（677C>T）多态性位点突变率为50.0%（8例）。2.氟尿嘧啶相关基因18DPYD*2A（476002G>A）GG型、153DPYD*13（1679T>G）TT型、154DPYD（2846A>T）TT型，且合成DPYD酶活性正常。3.紫杉醇相关基因62ABCB 1（3435T>C）CC型的血液毒性和神经毒性发生率低于CT型和TT型。13ABCB1（2677T>G）GG型耐药率高于TT型。14CYP1B1*3（C>G）CC型有较高的无进展生存期。铂相关基因21GSTP1（313A>G）AA为纯合野生型，其血液毒性发生率高于GA型。29XRCC1（1196T>C）CC为纯合子突变型，发生严重中性粒细胞减少症的风险高于CT型。62ABCB1（3435T>C）CC为纯合突变型，其淋巴结转移危险性高于TC型和TT型。68MTHFR（677C>T）TT型为纯合突变型，其粘膜毒性和毒副作用均高于CT型和CC型。结论：单核苷酸多态性与化疗的毒副作用有关，检测SNP预测吸毒者的毒性风险可作为指导临床个体化治疗的重要参考指标。
Objective: Investigating the relationship between single nucleotide polymorphisms (SNPs) and the toxic and adverse effects of paclitaxel and platinum-based chemotherapy in patients with malignant tumors, to provide recommendations for individualized treatment. .Methods: Determinate 17 patients with malignant tumor DNA site and analysis. .Results: 1. All 17 selected specimens’ fluorouracil related genes 18DPYD*2A(476002G>A)GG type、153DPYD*13(1679T>G)TT type 154DPYD(2846A>T)TT type, and the synthesis of DPYD enzyme activity. 21GSTP1(313A>G) polymorphism site mutation rate was 25.0%(4 cases), 29XRCC1(16323944T>C).polymorphism site mutation rate was 90.9%(10 cases), 62ABCB1(3435C>T) polymorphism site mutation rate was 52.9%(9 cases), and 68MTHFR(677C>T) polymorphism site mutation rate was 50.0%(8 cases). 2. Fluorouracil related genes 18DPYD*2A(476002G>A)GG type, 153DPYD*13(1679T>G)TT type, 154DPYD(2846A>T)TT type ,and the synthesis DPYD enzyme activity is normal. 3. Paclitaxel related genes 62ABCB1(3435T>C) CC type has a lower incidence of hematotoxicity and neurotoxicity, than CT type and TT type. 13ABCB1(2677T>G)GG type has a higher rate of drug resistance than TT type. 14CYP1B1*3(C>G)CC type has a higher progression-free survival. Platinum-related genes 21GSTP1(313A>G)AA is homozygous wild type and has a higher incidence of hematotoxicity than GA type. 29XRCC1(1196T>C)CC is homozygous mutant and has a higher risk of serious neutropenia than CT type. 62ABCB1 (3435T>C)CC is homozygous mutant and has a higher risk of lymphatic metastasis than TC type and TT type. 68MTHFR(677C>T)TT type is homozygous mutant and has a higher mucosal toxicity and toxic and side effects than CT type and CC type. .Conclusion: Single nucleotide polymorphism is related to the toxic and side effects of chemotherapy，the detection of SNP to predict the toxicity risk of drug users can be an important reference index to guide clinical individualized treatment.
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影响因子：
3.7
作者：
Yi L;Xiao-Feng H;Yun-Tao L;Hao L;Ye S;Song-Tao Q
通讯作者：
Song-Tao Q
影响因子：
11.2
作者：
Shen Mr;Jones Im;H. Mohrenweiser
通讯作者：
Shen Mr;Jones Im;H. Mohrenweiser
DOI：
--
发表时间：
2005-03
期刊：
Yi chuan = Hereditas
影响因子：
--
作者：
Xiu-Li Gao;Jian-Bo Yang;F. Jing;Jian-long Zhao
通讯作者：
Xiu-Li Gao;Jian-Bo Yang;F. Jing;Jian-long Zhao
影响因子：
--
作者：
Palmirotta R;Carella C;Silvestris E;Cives M;Stucci SL;Tucci M;Lovero D;Silvestris F
通讯作者：
Silvestris F
DOI：
--
发表时间：
2011
期刊：
Journal of Jilin University
影响因子：
--
作者：
Lu Zhen-xia
通讯作者：
Lu Zhen-xia