Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe.
Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe.
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欧洲埃可病毒30的分子流行病学和进化轨迹。
DOI：
10.3201/eid2706.203096
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发表时间：
2021-06
影响因子：
11.8
通讯作者：
Simmonds P
中科院分区：
文献类型：
--
作者：
Benschop KSM;Broberg EK;Hodcroft E;Schmitz D;Albert J;Baicus A;Bailly JL;Baldvinsdottir G;Berginc N;Blomqvist S;Böttcher S;Brytting M;Bujaki E;Cabrerizo M;Celma C;Cinek O;Claas ECJ;Cremer J;Dean J;Dembinski JL;Demchyshyna I;Diedrich S;Dudman S;Dunning J;Dyrdak R;Emmanouil M;Farkas A;De Gascun C;Fournier G;Georgieva I;Gonzalez-Sanz R;van Hooydonk-Elving J;Jääskeläinen AJ;Jancauskaite R;Keeren K;Fischer TK;Krokstad S;Nikolaeva-Glomb L;Novakova L;Midgley SE;Mirand A;Molenkamp R;Morley U;Mossong J;Muralyte S;Murk JL;Nguyen T;Nordbø SA;Österback R;Pas S;Pellegrinelli L;Pogka V;Prochazka B;Rainetova P;Van Ranst M;Roorda L;Schuffenecker I;Schuurman R;Stoyanova A;Templeton K;Verweij JJ;Voulgari-Kokota A;Vuorinen T;Wollants E;Wolthers KC;Zakikhany K;Neher R;Harvala H;Simmonds P
In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016–2018. Most E30 cases affected persons 0–4 years of age (29%) and 25–34 years of age (27%). Sequences were divided into 6 genetic clades (G1–G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections.
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