2009 pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States.
2009 pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States.
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DOI：
10.2353/ajpath.2010.100115
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Zaki SR
中科院分区：
文献类型：
--
作者：
Shieh WJ;Blau DM;Denison AM;Deleon-Carnes M;Adem P;Bhatnagar J;Sumner J;Liu L;Patel M;Batten B;Greer P;Jones T;Smith C;Bartlett J;Montague J;White E;Rollin D;Gao R;Seales C;Jost H;Metcalfe M;Goldsmith CS;Humphrey C;Schmitz A;Drew C;Paddock C;Uyeki TM;Zaki SR
2009年春季，一种新型甲型H1N1流感病毒在北美出现并在全球范围内传播，导致自1968年以来的第一次流感大流行。在前4个月，美国有500多人死亡与确诊的2009年甲型H1N1流感病毒感染有关。对最初流感相关死亡的呼吸道标本的病理学评价表明，与季节性流感相比，病毒嗜性和组织损伤有显著差异，并促使进一步调查。可用的尸检组织样本来自100例实验室确认的2009年H1N1病毒感染的美国死亡病例。收集这些病例患者的人口统计学和临床资料，并通过多种实验室方法对组织进行评价，包括组织病理学评价、特殊染色、分子和免疫组化检测、病毒培养和电子显微镜。观察到的最突出的组织病理学特征是弥漫性肺泡损伤的肺在所有的情况下，患者检查。肺泡衬里细胞，包括I型和II型肺细胞，是主要的感染细胞。在>25%的病例患者中确定了细菌合并感染。病毒性肺炎和病毒抗原的免疫定位与弥漫性肺泡损伤相关，是2009年甲型H1N1流感病毒感染的显著特征。基础医学状况和细菌合并感染导致了该感染的致死性结局。需要更多的研究来了解这种感染的多因素发病机制。
In the spring of 2009, a novel influenza A (H1N1) virus emerged in North America and spread worldwide to cause the first influenza pandemic since 1968. During the first 4 months, over 500 deaths in the United States had been associated with confirmed 2009 pandemic influenza A (H1N1) [2009 H1N1] virus infection. Pathological evaluation of respiratory specimens from initial influenza-associated deaths suggested marked differences in viral tropism and tissue damage compared with seasonal influenza and prompted further investigation. Available autopsy tissue samples were obtained from 100 US deaths with laboratory-confirmed 2009 H1N1 virus infection. Demographic and clinical data of these case-patients were collected, and the tissues were evaluated by multiple laboratory methods, including histopathological evaluation, special stains, molecular and immunohistochemical assays, viral culture, and electron microscopy. The most prominent histopathological feature observed was diffuse alveolar damage in the lung in all case-patients examined. Alveolar lining cells, including type I and type II pneumocytes, were the primary infected cells. Bacterial co-infections were identified in >25% of the case-patients. Viral pneumonia and immunolocalization of viral antigen in association with diffuse alveolar damage are prominent features of infection with 2009 pandemic influenza A (H1N1) virus. Underlying medical conditions and bacterial co-infections contributed to the fatal outcome of this infection. More studies are needed to understand the multifactorial pathogenesis of this infection.
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影响因子：
168.9
作者：
Echevarria-Zuno, Santiago;Manuel Mejia-Arangure, Juan;Hugo Borja-Aburto, Victor
通讯作者：
Hugo Borja-Aburto, Victor
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/0002-9378(59)90570-8
发表时间：
1959-01-01
影响因子：
9.8
作者：
FREEMAN, DW
通讯作者：
FREEMAN, DW
影响因子：
3.5
作者：
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通讯作者：
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