Subject-specific knee joint geometry improves predictions of medial tibiofemoral contact forces.
Subject-specific knee joint geometry improves predictions of medial tibiofemoral contact forces.
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DOI：
10.1016/j.jbiomech.2013.09.005
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发表时间：
2013-11-15
影响因子：
2.4
通讯作者：
Lloyd DG
中科院分区：
文献类型：
--
作者：
Gerus P;Sartori M;Besier TF;Fregly BJ;Delp SL;Banks SA;Pandy MG;D'Lima DD;Lloyd DG
估计胫股关节接触力对于了解膝关节骨关节炎的发生和进展非常重要。然而，胫股接触力预测受到许多因素的影响，包括肌肉力量和膝关节的解剖表示。本研究旨在研究受试者特定几何结构和膝关节运动学对使用校准的EMG驱动的膝关节神经肌肉骨骼模型预测胫股接触力的影响。一名装有仪器的全膝关节置换术的参与者以自选的速度行走，同时测量内侧和外侧胫股接触力、地面反作用力、全身运动学和下肢肌肉活动。通用和受试者特定的膝关节几何形状和运动学的组合产生了四种不同的OpenSim模型，用于估计肌肉肌腱长度和力臂。根据CT扫描创建受试者特定几何模型，并根据荧光透视获得代表胫骨相对于股骨平移的受试者特定膝关节运动学。使用一次行走试验校准EMG驱动模型，但使用三种不同的成本函数跟踪膝关节屈曲/伸展力矩，并对估计的关节接触力进行约束。然后，校准模型预测了其他五种不同步行试验的内侧和外侧胫股接触力。与使用通用肌肉骨骼模型相比，使用受试者特定模型（最大化胫股接触力峰值）将内侧接触力的准确性分别提高了47%和外侧接触力的准确性提高了7%。
Estimating tibiofemoral joint contact forces is important for understanding the initiation and progression of knee osteoarthritis. However, tibiofemoral contact force predictions are influenced by many factors including muscle forces and anatomical representations of the knee joint. This study aimed to investigate the influence of subject-specific geometry and knee joint kinematics on the prediction of tibiofemoral contact forces using a calibrated EMG-driven neuromusculoskeletal model of the knee. One participant fitted with an instrumented total knee replacement walked at a self-selected speed while medial and lateral tibiofemoral contact forces, ground reaction forces, whole-body kinematics, and lower-limb muscle activity were simultaneously measured. The combination of generic and subject-specific knee joint geometry and kinematics resulted in four different OpenSim models used to estimate muscle-tendon lengths and moment arms. The subject-specific geometric model was created from CT scans and the subject-specific knee joint kinematics representing the translation of the tibia relative to the femur was obtained from fluoroscopy. The EMG-driven model was calibrated using one walking trial, but with three different cost functions that tracked the knee flexion/extension moments with and without constraint over the estimated joint contact forces. The calibrated models then predicted the medial and lateral tibiofemoral contact forces for five other different walking trials. The use of subject-specific models with minimization of the peak tibiofemoral contact forces improved the accuracy of medial contact forces by 47% and lateral contact forces by 7%, respectively compared with the use of generic musculoskeletal model.
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影响因子：
3.7
作者：
Sartori M;Reggiani M;Farina D;Lloyd DG
通讯作者：
Lloyd DG
影响因子：
2.8
作者：
Kumar, Deepak;Rudolph, Katherine S.;Manal, Kurt T.
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Manal, Kurt T.
跑步过程中肌肉对推进和支撑的贡献。
影响因子：
2.4
作者：
Hamner, Samuel R.;Seth, Ajay;Delp, Scott L.
通讯作者：
Delp, Scott L.
影响因子：
1.8
作者：
Heiden, Tamika L.;Lloyd, David G.;Ackland, Timothy R.
通讯作者：
Ackland, Timothy R.
影响因子：
2.4
作者：
Donnelly, C. J.;Lloyd, D. G.;Reinbolt, J. A.
通讯作者：
Reinbolt, J. A.