The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria.
The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria.
复制标题
孟买作为对药物抗药性细菌的新抗生素的发展。
作者：
bengamides包括从属于多产Jaspidae家族的海绵中分离的有趣的天然产物家族。它们突出的抗肿瘤特性，加上它们独特的作用机制和前所未有的分子结构，促使了针对它们的全合成，类似物设计和生物学评价的强烈研究活动，以开发新的抗癌药物。近年来，苯甲酰胺类化合物与癌症研究中的这些生物学研究一起，由于其对各种耐药细菌如结核分枝杆菌和金黄色葡萄球菌的令人印象深刻的生物活性，已被确定为潜在的抗生素。本文综述了近年来苯甲酰胺类化合物在化学和生物学方面的新进展，特别关注其作为有前途的新型抗生素的开发。因此，详细描述了bengamides从最初作为抗肿瘤剂的探索到目前作为抗生素的地位的演变，突出了这些海洋天然产物作为药物化学中有效命中物的多种价值。
The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and unprecedented molecular structures, have prompted an intense research activity directed towards their total syntheses, analogue design, and biological evaluations for their development as new anticancer agents. Together with these biological studies in cancer research, in recent years, the bengamides have been identified as potential antibiotics by their impressive biological activities against various drug-resistant bacteria such as Mycobacterium tuberculosis and Staphylococcus aureus. This review reports on the new advances in the chemistry and biology of the bengamides during the last years, paying special attention to their development as promising new antibiotics. Thus, the evolution of the bengamides from their initial exploration as antitumor agents up to their current status as antibiotics is described in detail, highlighting the manifold value of these marine natural products as valid hits in medicinal chemistry.
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影响因子：
5.1
作者：
Sashidhara, Koneni V.;White, Kimberly N.;Crews, Phillip
通讯作者：
Crews, Phillip
影响因子：
4
作者：
Compton, Corey L.;Schmitz, Karl R.;Sauer, Robert T.;Sello, Jason K.
通讯作者：
Sello, Jason K.
影响因子：
5.2
作者：
Boeckman, RK;Clark, TJ;Shook, BC
通讯作者：
Shook, BC
DOI：
10.1073/pnas.95.26.15183
发表时间：
1998-12-22
影响因子：
11.1
作者：
Griffith, EC;Su, Z;Liu, JO
通讯作者：
Liu, JO
影响因子：
--
作者：
Hu, Xiaoyi;Dang, Yongjun;Liu, Jun O.
通讯作者：
Liu, Jun O.