A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products.
A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products.
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DOI：
10.1021/np800817y
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发表时间：
2009-03-27
影响因子：
5.1
通讯作者：
Crews, Phillip
中科院分区：
文献类型：
--
作者：
Sashidhara, Koneni V.;White, Kimberly N.;Crews, Phillip
海洋天然产物仍然是一个重要的分子结构的来源，作为刺激种子进一步的重大研究。这篇文章回顾了加州大学圣克鲁斯分校三十多年来在海洋生物分子研究方面取得的一些重大进展。我们将以全面的方式介绍发现和表征我们称之为“鼓舞人心的分子结构”的持续挑战。特殊分子结构的例子及其对生物医学研究的影响将是一个重要的主题。探索的三个主要生物群体包括：海藻、海绵和海洋衍生真菌，它们的活性原理的研究极大地受益于与学术和生物制药团体的协同合作。本编年史的最后部分将涉及涉及新来源和战略的未来成果的前景。
Marine natural products continue to be a source of significant molecular structures that serve as a stimulus to seed further significant research. This account reviews some of the major advances in the study of marine biomolecules made at UC Santa Cruz over more than three decades. The continuing challenge of discovery and characterization of what we term “inspirational molecular structures”, will be presented in a comprehensive fashion. Examples of privileged molecular structures and their impact on biomedicinal research will be an important theme. The three major groups of organisms explored include: seaweeds, sponges, and marine derived fungi, and the study of their active principles has greatly benefited from synergistic collaborations with both academic and biopharmaceutical groups. The concluding sections of this chronicle will touch on prospects for future outcomes involving new sources and strategies.
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影响因子：
1.8
作者：
Abrell, LM;Borgeson, B;Crews, P
通讯作者：
Crews, P
影响因子：
7.3
作者：
Amagata, T;Rath, C;Crews, P
通讯作者：
Crews, P
影响因子：
5.1
作者：
Amagata, T;Whitman, S;Holman, TR
通讯作者：
Holman, TR
影响因子：
3.6
作者：
ADAMCZESKI, M;QUINOA, E;CREWS, P
通讯作者：
CREWS, P
影响因子：
3.5
作者：
Cichewicz, RH;Clifford, LJ;Crews, P
通讯作者：
Crews, P