Does nicotine modify the psychotoxic effect of methamphetamine? Assessment in terms of locomotor sensitization in mice.
Does nicotine modify the psychotoxic effect of methamphetamine? Assessment in terms of locomotor sensitization in mice.
复制标题
尼古丁会改变甲基苯丙胺的精神毒性作用吗？
DOI：
--
复制
发表时间：
1999
影响因子：
2
通讯作者：
H. Kuribara
中科院分区：
文献类型：
--
作者：
H. Kuribara
本研究研究了尼古丁对小鼠甲基苯丙胺运动致敏的影响，以评估尼古丁是否改变了甲基苯丙胺精神毒性作用的诱导和表达。虽然尼古丁（0.03-1 mg/kg s.c）在第一次给药时没有作用，但间隔3天的5次尼古丁给药逐渐产生了显著的运动刺激作用，并导致对甲基苯丙胺（2 mg/kg s.c）的敏感性增强（交叉致敏）。每隔3天给予5次甲基苯丙胺（2 mg/kg），不仅产生对甲基苯丙胺本身的运动致敏，而且产生对尼古丁（0.1-1 mg/kg）的交叉致敏。尼古丁（0.03-1 mg/kg）不影响甲基苯丙胺（2 mg/kg）对小鼠的运动刺激作用。然而，在5次重复给药期间，尼古丁的剂量依赖性降低了甲基苯丙胺运动刺激作用的渐进式增强。同时给予甲基苯丙胺和尼古丁（1 mg/kg）的小鼠对甲基苯丙胺的敏感性低于单独给予甲基苯丙胺的小鼠。此外，尼古丁（1 mg/kg）可抑制甲基苯丙胺致敏小鼠的运动刺激作用。这些结果表明，甲基苯丙胺和尼古丁产生对称的交叉致敏，尽管尼古丁可能抑制小鼠对甲基苯丙胺的运动致敏的诱导和表达。
In this study, effects of nicotine on locomotor sensitization to methamphetamine in mice were investigated to assess whether nicotine modified induction and expression of psychotoxic action of methamphetamine. Although nicotine (0.03-1 mg/kg s.c.) had no effect at first administration, 5-time nicotine administrations at 3-day intervals progressively developed a significant locomotor stimulant effect, and caused an enhanced sensitivity (cross-sensitization) to methamphetamine (2 mg/kg s.c.). Five-time administrations of methamphetamine (2 mg/kg) at 3-day intervals produced not only a locomotor sensitization to methamphetamine itself, but also a cross-sensitization to nicotine (0.1-1 mg/kg). Nicotine (0.03-1 mg/kg) did not affect the locomotor stimulant effect of methamphetamine (2 mg/kg) in the drug-naive mice. However, nicotine acted dose-dependently to reduce the progressive enhancement of the locomotor stimulant effect of methamphetamine during 5-time repeated administrations. Mice treated with coadministration of methamphetamine with nicotine (1 mg/kg) showed less sensitization to methamphetamine than mice treated with methamphetamine alone. In addition, nicotine (1 mg/kg) inhibited the locomotor stimulant effect of methamphetamine in mice sensitized to methamphetamine. These results suggest that methamphetamine and nicotine produce a symmetrical cross-sensitization, although nicotine may act to inhibit the induction and expression of locomotor sensitization to methamphetamine in mice.
影响因子：
3.6
作者：
M. Marks;J. Stitzel;E. Romm;J. Wehner;A. C. Collins
通讯作者：
M. Marks;J. Stitzel;E. Romm;J. Wehner;A. C. Collins