Emergence and evolution of the renin-angiotensin-aldosterone system.
Emergence and evolution of the renin-angiotensin-aldosterone system.
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DOI：
10.1007/s00109-012-0894-z
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发表时间：
2012-05
影响因子：
4.7
通讯作者：
Andrade-Navarro, Miguel A.
中科院分区：
文献类型：
--
作者：
Fournier, David;Luft, Friedrich C.;Bader, Michael;Ganten, Detlev;Andrade-Navarro, Miguel A.
关键词：
肾素-血管紧张素-醛固酮系统（RAAS）不是唯一的，但可能是脊椎动物中最重要的容量调节器。为了深入了解其组成部分的功能和进化，我们对其主要相关基因进行了系统发育分析。我们发现，该系统的重要组成部分开始出现与原始脊索动物和被囊动物，所有主要成分都存在于分歧的硬骨鱼，与Mas受体的例外。Mas受体首先出现在骨鱼/四足动物分化之后。这一阶段的进化创新发生在大约4亿年前。我们发现了血管紧张素原在软骨鱼中出现的确凿证据。在缺乏所有组成部分的生物体中存在几个RAAS基因，表明这些基因在其当前作用之外具有其他祖先功能。我们的分析强调了序列比较在进化研究中的实用性。这样的分析可能会提供新的假设，如何以及为什么在今天的人口活动增加的RAAS经常导致错误的盐和容量调节，高血压和心血管疾病，开辟了新的和临床重要的研究领域的进化医学。本文的在线版本（doi：10.1007/s 00109 -012-0894-z）包含补充材料，可供授权用户使用。
The renin–angiotensin–aldosterone system (RAAS) is not the sole, but perhaps the most important volume regulator in vertebrates. To gain insights into the function and evolution of its components, we conducted a phylogenetic analysis of its main related genes. We found that important parts of the system began to appear with primitive chordates and tunicates and that all major components were present at the divergence of bony fish, with the exception of the Mas receptor. The Mas receptor first appears after the bony-fish/tetrapod divergence. This phase of evolutionary innovation happened about 400 million years ago. We found solid evidence that angiotensinogen made its appearance in cartilage fish. The presence of several RAAS genes in organisms that lack all the components shows that these genes have had other ancestral functions outside of their current role. Our analysis underscores the utility of sequence comparisons in the study of evolution. Such analyses may provide new hypotheses as to how and why in today's population an increased activity of the RAAS frequently leads to faulty salt and volume regulation, hypertension, and cardiovascular diseases, opening up new and clinically important research areas for evolutionary medicine. The online version of this article (doi:10.1007/s00109-012-0894-z) contains supplementary material, which is available to authorized users.
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影响因子：
2.7
作者：
Bury, Nicolas R.;Sturm, Armin
通讯作者：
Sturm, Armin
影响因子：
4.8
作者：
CORNEL, MJ;WILLIAMS, TA;ISAAC, RE
通讯作者：
ISAAC, RE
DOI：
10.1046/j.1432-1327.1998.2570599.x
发表时间：
1998-11-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Houard, X;Williams, TA;Corvol, P
通讯作者：
Corvol, P
影响因子：
5.8
作者：
Larkin, M. A.;Blackshields, G.;Higgins, D. G.
通讯作者：
Higgins, D. G.
影响因子：
64.8
作者：
MULLINS, JJ;PETERS, J;GANTEN, D
通讯作者：
GANTEN, D