Chronic vs. acute interactions between supraoptic oxytocin neurons and astrocytes during lactation: role of glial fibrillary acidic protein plasticity.
Chronic vs. acute interactions between supraoptic oxytocin neurons and astrocytes during lactation: role of glial fibrillary acidic protein plasticity.
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DOI：
10.1100/tsw.2009.148
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发表时间：
2009-11-18
影响因子：
--
通讯作者：
Hamilton K
中科院分区：
文献类型：
--
作者：
Wang YF;Hamilton K
在本文中，我们回顾了星形胶质细胞-神经元相互作用及其对大细胞下丘脑-神经垂体系统内催产素（OXT）神经元活性影响的研究。先前数十年的研究表明，星形胶质细胞过程的撤回会增加哺乳期间下丘脑视上核（SON）中 OXT 神经元的兴奋性。然而，长期禁用星形胶质细胞退缩不会显着影响哺乳期间 OXT 神经元的功能。然而，星形胶质细胞的细胞骨架成分——胶质纤维酸性蛋白（GFAP）的急剧变化与哺乳期间 OXT 神经元活性的变化同时发生。在这里，我们将 GFAP 和相关蛋白质的这些变化与整个哺乳期持续的慢性变化进行比较。在哺乳期间，GFAP 水平的降低伴随着 SON 中 OXT 神经元周围星形胶质细胞突起的回缩，这是由高细胞外 OXT 水平引起的。在哺乳的初始阶段，OXT 水平的急剧增加进一步加强了 GFAP 的减少并促进星形胶质细胞过程的回缩。这种变化反过来又促进了 OXT 神经元的爆发放电，并导致兴奋性神经化学物质的短暂增加。这种短暂的神经化学物质激增会逆转 GFAP 的表达，并导致 OXT 神经元的后爆发抑制。哺乳期间星形胶质细胞 GFAP 水平的急剧变化可能会周期性地重复出现，并伴有谷氨酸代谢、水运输、胶质递质释放以及星形胶质细胞和 OXT 神经元之间空间关系的节律变化。在神经垂体中，星形胶质细胞回缩和逆转以及伴随的 GFAP 可塑性也可能发生在哺乳期和哺乳期间，这促进了 OXT 的释放与其在 SON 中的作用相协调。这些对 GFAP 介导的星形胶质细胞和 OXT 神经元之间发生的动态相互作用的研究扩展了我们对中枢神经系统内星形胶质细胞功能的理解。
In this article, we review studies of astrocytic-neuronal interactions and their effects on the activity of oxytocin (OXT) neurons within the magnocellular hypothalamo-neurohypophysial system. Previous work over several decades has shown that withdrawal of astrocyte processes increases OXT neuron excitability in the hypothalamic supraoptic nucleus (SON) during lactation. However, chronically disabling astrocyte withdrawal does not significantly affect the functioning of OXT neurons during suckling. Nevertheless, acute changes in a cytoskeletal element of astrocytes, glial fibrillary acidic protein (GFAP), occur in concert with changes in OXT neuronal activity during suckling. Here, we compare these changes in GFAP and related proteins with chronic changes that persist throughout lactation. During lactation, a decrease in GFAP levels accompanies retraction of astrocyte processes surrounding OXT neurons in the SON, resulting from high extracellular levels of OXT. During the initial stage of suckling, acute increases in OXT levels further strengthen this GFAP reduction and facilitate the retraction of astrocyte processes. This change, in turn, facilitates burst discharges of OXT neurons and leads to a transient increase in excitatory neurochemicals. This transient neurochemical surge acts to reverse GFAP expression and results in postburst inhibition of OXT neurons. The acute changes in astrocyte GFAP levels seen during suckling likely recur periodically, accompanied by rhythmic changes in glutamate metabolism, water transport, gliotransmitter release, and spatial relationships between astrocytes and OXT neurons. In the neurohypophysis, astrocyte retraction and reversal with accompanying GFAP plasticity also likely occur during lactation and suckling, which facilitates OXT release coordinated with its action in the SON. These studies of the dynamic interactions that occur between astrocytes and OXT neurons mediated by GFAP extend our understanding of astrocyte functions within the central nervous system.
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DOI：
10.1152/ajpendo.1998.274.3.e453
发表时间：
1998-03-01
影响因子：
5.1
作者：
Bealer, SL;Crowley, WR
通讯作者：
Crowley, WR
影响因子：
2.9
作者：
Bernardinelli, Yann;Chatton, Jean-Yves
通讯作者：
Chatton, Jean-Yves
影响因子：
--
作者：
Cohen, Jonathan E.;Fields, R. Douglas
通讯作者：
Fields, R. Douglas
影响因子：
3.2
作者：
Douglas, AJ;Bicknell, RJ;Meddle, SL
通讯作者：
Meddle, SL
影响因子：
3.3
作者：
HATTON, GI;YANG, QZ;COBBETT, P
通讯作者：
COBBETT, P