Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction.
Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction.
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DOI：
10.1186/s13578-023-01009-3
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发表时间：
2023-03-16
影响因子：
7.5
通讯作者：
Zhang, Yuanyuan
中科院分区：
文献类型：
--
作者：
Shan, Shengzhou;Li, Qingfeng;Criswell, Tracy;Atala, Anthony;Zhang, Yuanyuan
关键词：
括约肌功能障碍通常发生在小管器官的末端，如尿道、肛门或胃食管括约肌。它是由创伤、炎症和衰老引起的神经肌肉损伤的主要后果。尽管努力恢复括约肌功能，药物治疗没有取得显着的改善。基于细胞或生长因子的治疗是神经肌肉再生和括约肌功能恢复的一种有前途的方法。然而，细胞保留和活力的降低，或植入后生长因子的短半衰期和快速降解，仍然是这些疗法向临床转化的障碍。天然生物材料为受控生长因子递送提供了独特的工具，与单一疗法相比，当干细胞和生长因子共同施用时，其导致体内括约肌功能恢复的更好结果。在这篇综述中，我们讨论了干细胞与生长因子的控释相结合的作用，用于交付的方法，其在神经肌肉修复中的潜在治疗作用，以及使用联合治疗的临床前研究的结果，希望提供新的治疗策略来治疗尿失禁或尿道，肛门或胃食管组织的括约肌功能障碍，分别。
Sphincter dysfunction often occurs at the end of tubule organs such as the urethra, anus, or gastroesophageal sphincters. It is the primary consequence of neuromuscular impairment caused by trauma, inflammation, and aging. Despite intensive efforts to recover sphincter function, pharmacological treatments have not achieved significant improvement. Cell- or growth factor-based therapy is a promising approach for neuromuscular regeneration and the recovery of sphincter function. However, a decrease in cell retention and viability, or the short half-life and rapid degradation of growth factors after implantation, remain obstacles to the translation of these therapies to the clinic. Natural biomaterials provide unique tools for controlled growth factor delivery, which leads to better outcomes for sphincter function recovery in vivo when stem cells and growth factors are co-administrated, in comparison to the delivery of single therapies. In this review, we discuss the role of stem cells combined with the controlled release of growth factors, the methods used for delivery, their potential therapeutic role in neuromuscular repair, and the outcomes of preclinical studies using combination therapy, with the hope of providing new therapeutic strategies to treat incontinence or sphincter dysfunction of the urethra, anus, or gastroesophageal tissues, respectively.
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