Effects of Microgravity on Early Embryonic Development and Embryonic Stem Cell Differentiation: Phenotypic Characterization and Potential Mechanisms.

Effects of Microgravity on Early Embryonic Development and Embryonic Stem Cell Differentiation: Phenotypic Characterization and Potential Mechanisms.
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DOI:
10.3389/fcell.2021.797167
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发表时间:
2021
影响因子:
5.5
通讯作者:
Zhang W
Zhang W
中科院分区:
生物学2区
文献类型:
--
作者:
Li F;Ye Y;Lei X;Zhang W

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随着科学技术的发展,人类对外层空间的探索大大增加。在外太空或其他星球定居可以帮助解决地球的资源危机,但这种定居首先面临的是繁殖问题。外层空间与地球环境之间存在着相当大的差异,重力的影响是其中最显著的差异之一。研究微重力对胚胎干细胞(ESC)分化和胚胎发育的可能影响和潜在机制,有助于为深空健康生活和生殖提供解决方案。本文综述了微重力对胚胎干细胞及早期胚胎发育影响的研究进展,并提出了可能的机制假说。此外,我们讨论了该领域的争议和关键问题,并指出未来的研究方向。
With the development of science and technology, mankind’s exploration of outer space has increased tremendously. Settling in outer space or on other planets could help solve the Earth’s resource crisis, but such settlement will first face the problem of reproduction. There are considerable differences between outer space and the Earth’s environment, with the effects of gravity being one of the most significant. Studying the possible effects and underlying mechanisms of microgravity on embryonic stem cell (ESC) differentiation and embryonic development could help provide solutions to healthy living and reproduction in deep space. This article summarizes recent research progress on the effects of microgravity on ESCs and early embryonic development and proposes hypotheses regarding the potential mechanisms. In addition, we discuss the controversies and key questions in the field and indicate directions for future research.
暴露于抛物线飞行诱导的急性超高和微重力的鼠类胚胎干细胞中分化过程的调节。
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