Triamcinolone acetonide injectable suspension for suprachoroidal use in the treatment of macular edema associated with uveitis.
Triamcinolone acetonide injectable suspension for suprachoroidal use in the treatment of macular edema associated with uveitis.
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DOI：
10.1080/17469899.2022.2114456
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发表时间：
2022
影响因子：
0.7
通讯作者：
Yeh, Steven
中科院分区：
文献类型：
--
作者：
Thomas, Joanne;Kim, Lucas;Albini, Thomas;Yeh, Steven
非感染性葡萄膜炎引起的黄斑水肿是一种威胁视力的并发症，常规使用皮质类固醇治疗。曲安奈德脉络膜上注射混悬剂(XIPERE™)是非感染性葡萄膜炎相关黄斑水肿患者的替代治疗选择。本综述描述了最近FDA批准的曲安奈德可注射混悬剂，该混悬剂可以注射到脉络膜上腔。这个生理间隙位于巩膜和脉络膜之间。这允许治疗性靶向视网膜和脉络膜。这篇综述重点介绍了已发表的这种新药制剂的临床试验。在非感染性葡萄膜炎相关黄斑水肿的研究中，脉络膜上注射曲安奈德显示了视力和炎症的改善。这种独特的给药方法提示有可能减少眼前段暴露的副作用，如青光眼和白内障，但安全性和有效性的进一步研究还需要进行面对面的试验。此外，脉络膜上间隙用于其他疾病，包括黄斑变性、糖尿病黄斑水肿和眼肿瘤，也有很有前景的研究正在进行中。
Macular edema due to noninfectious uveitis is a sight-threatening complication that is routinely treated with corticosteroids. Triamcinolone acetonide injectable suspension for suprachoroidal use (Xipere™) is an alternative treatment option for patients with non-infectious uveitis associated macular edema. This review describes the recently FDA approved triamcinolone acetonide injectable suspension that can be injected into the suprachoroidal space. This physiological space is between the sclera and choroid. This allows for therapeutic targeting of the retina and choroid. This review highlights published clinical trials for this novel drug preparation. Suprachoroidal administration of triamcinolone acetonide has shown improvement in vision and inflammation in studies with non-infectious uveitis associated macular edema. This unique delivery method suggests the potential to decrease side effects of anterior segment exposure such as glaucoma and cataract, but head-to-head trials are needed for further study of safety and efficacy. Additionally, there are promising prospective studies underway for utilization of the suprachoroidal space for other diseases including macular degeneration, diabetic macular edema, and ocular tumors.
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影响因子：
3.3
作者：
Merrill, Pauline T.;Henry, Christopher R.;Ciulla, Thomas A.
通讯作者：
Ciulla, Thomas A.
DOI：
10.1159/000431198
发表时间：
2016-01-01
期刊：
RETINAL PHARMACOTHERAPEUTICS
影响因子：
--
作者：
Caceres-del-Carpio, Javier;Costa, Rodrigo Donato;Kuppermann, Baruch D.
通讯作者：
Kuppermann, Baruch D.
曲安西龙的甲状腺螺体注射 - 对非感染性葡萄膜炎引起的黄斑水肿的新型治疗方法。
DOI：
10.17925/usor.2020.13.2.76
发表时间：
2020
期刊：
US ophthalmic review
影响因子：
--
作者：
Price KW;Albini TA;Yeh S
通讯作者：
Yeh S
影响因子：
4.1
作者：
Khurana, Rahul N.;Merrill, Pauline;Yeh, Steven;Suhler, Eric;Barakat, Mark R.;Uchiyama, Eduardo;Henry, Christopher Ryan;Shah, Milan;Wang, Robert C.;Kapik, Barry;Ciulla, Thomas
通讯作者：
Ciulla, Thomas
影响因子：
4.4
作者：
Gilger, Brian C.;Abarca, Eva M.;Patel, Samirkumar
通讯作者：
Patel, Samirkumar