The role of microRNAs in breast cancer migration, invasion and metastasis.
The role of microRNAs in breast cancer migration, invasion and metastasis.
复制标题
microRNA在乳腺癌迁移，侵袭和转移中的作用。
DOI：
10.3390/ijms131013414
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发表时间：
2012-10-18
影响因子：
5.6
通讯作者：
Sarkar FH
中科院分区：
文献类型：
--
作者：
Tang J;Ahmad A;Sarkar FH
microRNA（miRNAs）是一类主要的非编码小RNA分子，其通过靶向mRNA以触发翻译抑制或mRNA降解来调节基因表达。由于它们作为癌症治疗靶点的潜在作用，最近对其进行了更广泛的研究。许多miRNA与包括乳腺癌在内的多种人类癌症有关。已知miRNA调节细胞周期和发育，并且因此可作为用于抗癌疗法的探索的有用靶标。改变的miRNA特征与乳腺癌发展和转移之间的联系可以通过肿瘤抑制miRNA如let-7s、miR-30 a/31/34 a/125 s/200 s/203/205/206/342的丢失或致癌miRNA的过表达来观察，如乳腺癌细胞中的miR-10 b/21/135 a/155/221/222/224/373/520 c。其中一些miRNAs也在乳腺癌患者的肿瘤标本中得到了验证，强调了它们在诊断中的潜在作用，以及乳腺癌新疗法的靶点。在这篇综述文章中，我们将提供一个概述和更新，我们目前的理解，这些良好的特点在乳腺癌模型中的miRNA的作用方式。因此，更好地理解这些miRNAs所协调的基因网络可能有助于充分利用miRNAs在癌症诊断、治疗和治疗方面的潜力。
MicroRNAs (miRNAs) are a major class of small, noncoding RNA molecules that regulate gene expression by targeting mRNAs to trigger either translational repression or mRNA degradation. They have recently been more widely investigated due to their potential role as targets for cancer therapy. Many miRNAs have been implicated in several human cancers, including breast cancer. miRNAs are known to regulate cell cycle and development, and thus may serve as useful targets for exploration in anticancer therapeutics. The link between altered miRNA signatures and breast cancer development and metastasis can be observed either through the loss of tumor suppressor miRNAs, such as let-7s, miR-30a/31/34a/125s/200s/203/205/206/342 or the overexpression of oncogenic miRNAs, such as miR-10b/21/135a/155/221/222/224/373/520c in breast cancer cells. Some of these miRNAs have also been validated in tumor specimens of breast cancer patients, underscoring their potential roles in diagnostics, as well as targets for novel therapeutics for breast cancer. In this review article, we will provide an overview and update of our current understanding of the mode of action of several of these well characterized miRNAs in breast cancer models. Therefore, better understanding of the gene networks orchestrated by these miRNAs may help exploit the full potential of miRNAs in regards to cancer diagnosis, treatment, and therapeutics.
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影响因子：
14.9
作者：
Bhat-Nakshatri P;Wang G;Collins NR;Thomson MJ;Geistlinger TR;Carroll JS;Brown M;Hammond S;Srour EF;Liu Y;Nakshatri H
通讯作者：
Nakshatri H
影响因子：
11.2
作者：
Ahmad A;Aboukameel A;Kong D;Wang Z;Sethi S;Chen W;Sarkar FH;Raz A
通讯作者：
Raz A
影响因子：
11.2
作者：
Bracken, Cameron P.;Gregory, Philip A.;Goodall, Gregory J.
通讯作者：
Goodall, Gregory J.
影响因子：
4.7
作者：
Cittelly DM;Das PM;Salvo VA;Fonseca JP;Burow ME;Jones FE
通讯作者：
Jones FE
影响因子：
3.8
作者：
Cheng, Chun-Wen;Wang, Hsiao-Wei;Shen, Chen-Yang
通讯作者：
Shen, Chen-Yang