Thromboxane Synthesis by Sources Other Than Platelets in Association with Complement‐Induced Pulmonary Leukostasis and Pulmonary Hypertension in Sheep
Thromboxane Synthesis by Sources Other Than Platelets in Association with Complement‐Induced Pulmonary Leukostasis and Pulmonary Hypertension in Sheep
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血小板以外来源的血栓素合成与补体诱导的绵羊肺白细胞停滞和肺动脉高压相关
DOI：
10.1161/01.res.52.1.1
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发表时间：
1983
影响因子：
20.1
通讯作者：
J. Cooper
中科院分区：
文献类型：
--
作者：
J. Mcdonald;M. Ali;E. Morgan;E. Townsend;J. Cooper
将含有酵母聚糖激活补体的血浆输注到绵羊体内会导致白细胞减少、肺白细胞停滞和肺动脉高压。我们之前证明了肺血管反应与血浆血栓素升高之间的密切关系。我们研究了该模型中血栓素合成的来源。添加到全血中的含有酵母聚糖激活补体的血浆不会刺激血栓素合成。这一观察结果表明，白细胞不会直接响应补体而合成血栓素。通过给予抗血小板血清而导致严重血小板减少的绵羊以通常的方式对补体输注做出反应。阿司匹林（10 mg/kg）预处理可保护绵羊免受肺血管反应并完全阻断血栓素合成。输入功能性血小板并不能恢复这些反应。阿司匹林治疗后24小时，体内血栓素合成明显高于体外血小板血栓素合成。血栓烷由组织合成，该组织以比血小板周转更快的速度恢复环氧合酶活性。羊肺在体外活跃地合成血栓素。据推测，暴露于活化补体成分的白细胞会损伤肺血管内皮细胞并刺激血栓素A2的合成，从而导致肺血管收缩。
Infusion into sheep of plasma containing zymosan-activated complement produces leukopenia, pulmonary leukostasis, and pulmonary artery hypertension. We previously demonstrated a close relationship between the pulmonary vascular response and elevations of plasma thromboxane. We have investigated the source of thromboxane synthesis in this model. Plasma containing zymosan-activated complement added to whole blood did not stimulate thromboxane synthesis. This observation suggested that leukocytes do not synthesize thromboxane directly in response to complement. Sheep rendered severely thrombocytopenic by the administration of antiplatelet serum responded to complement infusion in the usual way. Pretreatment with aspirin (10 mg/kg) protected sheep against the pulmonary vascular response and completely blocked thromboxane synthesis. Transfusion of functional platelets did not restore these responses. Twentyfour hours after aspirin treatment, in vivo thromboxane synthesis was significantly greater than platelet thromboxane synthesis in vitro. Thromboxane is synthesized by a tissue which recovers cyclooxygenase enzyme activity at a rate that is more rapid than platelet turnover. Sheep lung synthesizes thromboxane actively in vitro. It is postulated that leukocytes exposed to activated complement components damage pulmonary vascular endothelial cells and stimulate synthesis of thromboxane A2 which causes pulmonary vasoconstriction.
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影响因子：
158.5
作者：
CHENOWETH, DE;COOPER, SW;KIRKLIN, JW
通讯作者：
KIRKLIN, JW
静水压和胶体渗透压在肾钠重吸收中的作用。
影响因子：
20.1
作者：
Knox,FG;Mertz,JI;BurnettJr,JC;Haramati,A
通讯作者：
Haramati,A
血小板减少羊部分体外循环期间血浆血栓素升高降低。
DOI：
--
发表时间：
1981
期刊：
Transactions - American Society for Artificial Internal Organs
影响因子：
--
作者：
Wonders,TR;Southmayd,JR;Schuette,AH;Huttemeier,PC;Kong,D;Watkins,WD;Carvalho,A;Zapol,WM
通讯作者：
Zapol,WM
压力感受反射对长期使用仪器的胎儿羔羊的循环的控制。
影响因子：
20.1
作者：
Itskovitz,J;LaGamma,EF;Rudolph,AM
通讯作者：
Rudolph,AM