HLungDB: an integrated database of human lung cancer research.
HLungDB: an integrated database of human lung cancer research.
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HLungDB：人类肺癌研究的综合数据库
DOI：
10.1093/nar/gkp945
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发表时间：
2010-01
影响因子：
14.9
通讯作者：
Shi T
中科院分区：
文献类型：
--
作者：
Wang L;Xiong Y;Sun Y;Fang Z;Li L;Ji H;Shi T
人类肺癌数据库是一个将肺癌相关基因、蛋白质和miRNAs与相应的临床信息整合在一起的数据库。该平台的主要目的是建立肺癌相关分子网络，促进肺癌发生机制的研究。当前版本中描述分子与人类肺癌之间关系的条目是从文献中手动提取的。目前，我们已经收集了2585个基因和212个miRNA，通过文本挖掘收集了参与肺癌发生不同阶段的实验证据。此外，我们还结合了对每个基因的转录因子结合基序、启动子和SNP位点的分析结果。由于表观遗传改变在肺癌的发生中也起着重要的作用，因此具有表观遗传调控的基因也被包括在内。我们希望HrungDB将丰富我们对肺癌生物学的知识，并最终导致新的治疗策略的开发。HLUNGDB可在http://www.megabionet.org/bio/hlung.上免费访问
The human lung cancer database (HLungDB) is a database with the integration of the lung cancer-related genes, proteins and miRNAs together with the corresponding clinical information. The main purpose of this platform is to establish a network of lung cancer-related molecules and to facilitate the mechanistic study of lung carcinogenesis. The entries describing the relationships between molecules and human lung cancer in the current release were extracted manually from literatures. Currently, we have collected 2585 genes and 212 miRNA with the experimental evidences involved in the different stages of lung carcinogenesis through text mining. Furthermore, we have incorporated the results from analysis of transcription factor-binding motifs, the promoters and the SNP sites for each gene. Since epigenetic alterations also play an important role in lung carcinogenesis, genes with epigenetic regulation were also included. We hope HLungDB will enrich our knowledge about lung cancer biology and eventually lead to the development of novel therapeutic strategies. HLungDB can be freely accessed at http://www.megabionet.org/bio/hlung.
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影响因子：
7.4
作者：
Rohrbeck A;Neukirchen J;Rosskopf M;Pardillos GG;Geddert H;Schwalen A;Gabbert HE;von Haeseler A;Pitschke G;Schott M;Kronenwett R;Haas R;Rohr UP
通讯作者：
Rohr UP
影响因子：
14.9
作者：
Keshava Prasad TS;Goel R;Kandasamy K;Keerthikumar S;Kumar S;Mathivanan S;Telikicherla D;Raju R;Shafreen B;Venugopal A;Balakrishnan L;Marimuthu A;Banerjee S;Somanathan DS;Sebastian A;Rani S;Ray S;Harrys Kishore CJ;Kanth S;Ahmed M;Kashyap MK;Mohmood R;Ramachandra YL;Krishna V;Rahiman BA;Mohan S;Ranganathan P;Ramabadran S;Chaerkady R;Pandey A
通讯作者：
Pandey A
影响因子：
--
作者：
Son, Ji-Woong;Kang, Hyo-Kyung;Park, Jae Yong
通讯作者：
Park, Jae Yong
影响因子：
11.2
作者：
Engels, Eric A.;Wu, Xifeng;Spitz, Margaret R.
通讯作者：
Spitz, Margaret R.
影响因子：
9.6
作者：
Devereux, TR;Taylor, JA;Barrett, JC
通讯作者：
Barrett, JC