Systematic Analysis of Mouse Genome Reveals Distinct Evolutionary and Functional Properties Among Circadian and Ultradian Genes.
Systematic Analysis of Mouse Genome Reveals Distinct Evolutionary and Functional Properties Among Circadian and Ultradian Genes.
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DOI：
10.3389/fphys.2018.01178
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发表时间：
2018
影响因子：
4
通讯作者：
Mazzoccoli G
中科院分区：
文献类型：
--
作者：
Castellana S;Mazza T;Capocefalo D;Genov N;Biagini T;Fusilli C;Scholkmann F;Relógio A;Hogenesch JB;Mazzoccoli G
在生物体中，生物钟调节24小时(昼夜节律)的分子、生理和行为节奏，以保持动态平衡和与可预测的环境变化同步，特别是与地球自转引起的环境变化保持同步。这些具有8小时和12小时周期的昼夜节律的和声已经在几个物种中被记录下来。在小鼠肝脏中，基因转录24小时周期的谐波标志着基因以比昼夜周期快两到三倍的频率振荡。许多这些和谐的转录本丰富了调节对环境胁迫的反应的途径，并优先与主观的黎明和黄昏重合。目前，具有节律表达的基因的进化史仍然鲜为人知，而由于过去40亿年来地球自转速度降低而导致的日长变化的作用也完全被忽视。我们假设，极端基因和压力预期基因在进化上比昼夜节律基因和背景非振荡基因更保守。为了研究这个问题，我们对几个物种中以不同频率振荡的基因/蛋白质进行了广泛的计算分析，结果表明，超传统基因/蛋白质，特别是那些以12小时为周期振荡的基因/蛋白质，更有可能是古老的起源和小鼠的必需基因/蛋白质。综上所述，我们的结果表明，具有超传统转录模式的基因更有可能在系统发育上是保守的，并与原始的和不可避免的黎明/黄昏过渡有关。
In living organisms, biological clocks regulate 24 h (circadian) molecular, physiological, and behavioral rhythms to maintain homeostasis and synchrony with predictable environmental changes, in particular with those induced by Earth’s rotation on its axis. Harmonics of these circadian rhythms having periods of 8 and 12 h (ultradian) have been documented in several species. In mouse liver, harmonics of the 24-h period of gene transcription hallmarked genes oscillating with a frequency two or three times faster than circadian periodicity. Many of these harmonic transcripts enriched pathways regulating responses to environmental stress and coinciding preferentially with subjective dawn and dusk. At this time, the evolutionary history of genes with rhythmic expression is still poorly known and the role of length-of-day changes due to Earth’s rotation speed decrease over the last four billion years is totally ignored. We hypothesized that ultradian and stress anticipatory genes would be more evolutionarily conserved than circadian genes and background non-oscillating genes. To investigate this issue, we performed broad computational analyses of genes/proteins oscillating at different frequency ranges across several species and showed that ultradian genes/proteins, especially those oscillating with a 12-h periodicity, are more likely to be of ancient origin and essential in mice. In summary, our results show that genes with ultradian transcriptional patterns are more likely to be phylogenetically conserved and associated with the primeval and inevitable dawn/dusk transitions.
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影响因子：
14.9
作者：
Huerta-Cepas J;Capella-Gutiérrez S;Pryszcz LP;Marcet-Houben M;Gabaldón T
通讯作者：
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影响因子：
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DOI：
10.1073/pnas.1612917113
发表时间：
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作者：
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