Vaccine technologies: From whole organisms to rationally designed protein assemblies.
Vaccine technologies: From whole organisms to rationally designed protein assemblies.
复制标题
疫苗技术：从整个生物到合理设计的蛋白质组件。
DOI：
10.1016/j.bcp.2016.05.001
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发表时间：
2016-11-15
影响因子：
5.8
通讯作者：
Burkhard, Peter
中科院分区：
文献类型：
--
作者：
Karch, Christopher P.;Burkhard, Peter
疫苗一直是公共卫生领域最显著的进步，每年可预防数百万人的发病和死亡。疫苗开发传统上侧重于全生物疫苗，要么是减毒活疫苗，要么是灭活疫苗。虽然对许多不同的传染病有效，但整个生物体的生产成本很高，需要培养感染剂，并有可能在宿主中引起疫苗相关疾病。随着技术的进步和开发安全、经济有效的候选疫苗的愿望，该领域开始专注于开发被称为亚单位疫苗的重组表达抗原。虽然耐受性更强，但亚单位疫苗的免疫原性往往较低。人们试图通过添加佐剂来提高免疫原性，佐剂可以是免疫刺激分子，也可以是增加对疫苗的免疫反应的抗原递送系统。人们非常感兴趣的一个领域是将纳米技术应用于疫苗开发，这使得抗原可以在颗粒递送系统上表达。纳米疫苗最令人兴奋的例子之一是合理设计的蛋白质纳米颗粒。这些纳米颗粒利用结构生物学、生物物理化学和疫苗学的一些基本知识来开发保护性、安全和易于制造的疫苗。合理开发的纳米疫苗是未来疫苗发展最有希望的候选者之一。
Vaccines have been the single most significant advancement in public health, preventing morbidity and mortality in millions of people annually. Vaccine development has traditionally focused on whole organism vaccines, either live attenuated or inactivated vaccines. While successful for many different infectious diseases whole organisms are expensive to produce, require culture of the infectious agent, and have the potential to cause vaccine associated disease in hosts. With advancing technology and a desire to develop safe, cost effective vaccine candidates, the field began to focus on the development of recombinantly expressed antigens known as subunit vaccines. While more tolerable, subunit vaccines tend to be less immunogenic. Attempts have been made to increase immunogenicity with the addition of adjuvants, either immunostimulatory molecules or an antigen delivery system that increases immune responses to vaccines. An area of extreme interest has been the application of nanotechnology to vaccine development, which allows for antigens to be expressed on a particulate delivery system. One of the most exciting examples of nanovaccines are rationally designed protein nanoparticles. These nanoparticles use some of the basic tenants of structural biology, biophysical chemistry, and vaccinology to develop protective, safe, and easily manufactured vaccines. Rationally developed nanoparticle vaccines are one of the most promising candidates for the future of vaccine development.
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影响因子：
6.2
作者：
Bode C;Zhao G;Steinhagen F;Kinjo T;Klinman DM
通讯作者：
Klinman DM
影响因子：
5.5
作者：
Braga, Catarina J. M.;Massis, Liliana M.;Ferreira, Luis C. S.
通讯作者：
Ferreira, Luis C. S.
影响因子：
6.2
作者：
Bovier, Patrick A.
通讯作者：
Bovier, Patrick A.
鞭毛蛋白融合蛋白的增强抗原加工可促进抗原特异性CD8+ T细胞反应，独立于TLR5和MYD88。
DOI：
10.4049/jimmunol.1001855
发表时间：
2011-06-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bates JT;Graff AH;Phipps JP;Grayson JM;Mizel SB
通讯作者：
Mizel SB
DOI：
10.1155/2011/126794
发表时间：
2011
期刊：
Influenza research and treatment
影响因子：
--
作者：
Babapoor S;Neef T;Mittelholzer C;Girshick T;Garmendia A;Shang H;Khan MI;Burkhard P
通讯作者：
Burkhard P