A Multifunctional Origami Patch for Minimally Invasive Tissue Sealing.
A Multifunctional Origami Patch for Minimally Invasive Tissue Sealing.
复制标题
用于微创组织凝闭的多功能折纸贴片。
DOI：
10.1002/adma.202007667
复制
发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Zhao X
中科院分区：
文献类型：
--
作者：
Wu SJ;Yuk H;Wu J;Nabzdyk CS;Zhao X
几十年来，生物粘附材料因其在微创外科手术中替代缝合线和斯台普斯密封组织的潜力而备受关注。然而，通过狭窄空间递送生物粘合剂和在富含流体的生理环境中实现强粘附的复杂性继续对现有密封剂的外科平移造成实质性限制。在这项工作中，我们介绍了一种基于多层生物粘附贴片的微创组织密封的新策略，该贴片旨在排斥体液，与湿组织形成快速的压力触发粘附，并抵抗生物污染和炎症。多功能贴片通过三个不同功能层的协同组合来实现：（i）微纹理生物粘附层，（ii）动态的、血液排斥的疏水流体层，和（iii）两性离子非粘附层。该贴片能够在血液存在下与组织表面形成牢固的粘附，并表现出对细菌粘附、纤维蛋白原吸附和体内纤维囊形成的上级抗性。通过采用基于折纸的制造策略，我们证明了补片可以很容易地与各种微创末端效应器集成，以在离体猪模型中提供轻松的组织凝闭，为各种临床场景中的微创组织凝闭提供了新的机会。多功能贴片为微创手术中的组织密封提供了新的机会。动态疏水流体层、微纹理生物粘附层和两性离子互穿弹性体层的整合使得贴片能够应用于富含流体的环境中，保持稳健的密封，并最小化生物污垢和炎症。通过采用用于各种外科末端执行器的基于折纸的设计策略，贴片可以适于适应一系列临床应用。
For decades, bioadhesive materials have garnered great attention due to their potential to replace sutures and staples for sealing tissues during minimally invasive surgical procedures. However, the complexities of delivering bioadhesives through narrow spaces and achieving strong adhesion in fluid-rich physiological environments continue to present substantial limitations to the surgical translation of existing sealants. In this work, we introduce a new strategy for minimally invasive tissue sealing based on a multilayer bioadhesive patch, which is designed to repel body fluids, form fast, pressure-triggered adhesion with wet tissues, and resist biofouling and inflammation. The multifunctional patch is realized by a synergistic combination of three distinct functional layers: (i) a micro-textured bioadhesive layer, (ii) a dynamic, blood-repellent hydrophobic fluid layer, and (iii) an antifouling zwitterionic non-adhesive layer. The patch is capable of forming robust adhesion to tissue surfaces in the presence of blood, and exhibits superior resistance to bacterial adhesion, fibrinogen adsorption, and in vivo fibrous capsule formation. By adopting origami-based fabrication strategies, we demonstrate that the patch can be readily integrated with a variety of minimally invasive end effectors to provide facile tissue sealing in ex vivo porcine models, offering new opportunities for minimally invasive tissue sealing in diverse clinical scenarios. A multifunctional patch presents new opportunities for sealing tissues in minimally invasive surgeries. Integration of a dynamic hydrophobic fluid layer, a micro-textured bioadhesive layer, and a zwitterionic-interpenetrated elastomer layer enables the patch to be applied in fluid-rich environments, maintain a robust seal, and minimize biofouling and inflammation. The patch can be adapted to suit a range of clinical applications by employing origami-based design strategies for various surgical end effectors.
登录
查看更多内容
DOI：
10.1016/j.ejpb.2015.05.022
发表时间：
2015-09
期刊：
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
影响因子：
--
作者：
Annabi N;Yue K;Tamayol A;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
25
作者：
Miyashita, Shuhei;Guitron, Steven;Rus, Daniela
通讯作者：
Rus, Daniela
影响因子：
120.7
作者：
Mack, MJ
通讯作者：
Mack, MJ
影响因子：
1.4
作者：
Murrell, Zuri A;Stamos, Michael J
通讯作者：
Stamos, Michael J
影响因子：
25
作者：
Rafsanjani, Ahmad;Zhang, Yuerou;Bertoldi, Katia
通讯作者：
Bertoldi, Katia